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In vivo transport of Gd-DTPA(2-) in human knee cartilage assessed by depth-wise dGEMRIC analysis.

Hawezi, Zana LU ; Lammentausta, Eveliina LU ; Svensson, Jonas LU ; Dahlberg, Leif LU and Tiderius, Carl Johan LU (2011) In Journal of Magnetic Resonance Imaging 34. p.1352-1358
Abstract
PURPOSE: To investigate the transport of Gd-DTPA(2-) in different layers of femoral knee cartilage in vivo. MATERIALS AND METHODS: T(1) measurements (1.5 Tesla) were performed in femoral knee cartilage of 23 healthy volunteers. The weight-bearing central cartilage was analyzed before contrast and at eight time points after an intravenous injection of Gd-DTPA(2-) : 12-60 min (4 volunteers) and 1-4 h (19 volunteers). Three regions of interest were segmented manually: deep, middle, and superficial. RESULTS: Before contrast injection, a depth-wise variation of T(1) was observed with 50% higher values in the superficial region compared with the deep region. In the deep region, the uptake of Gd-DTPA(2-) was not detected until 36 min and the... (More)
PURPOSE: To investigate the transport of Gd-DTPA(2-) in different layers of femoral knee cartilage in vivo. MATERIALS AND METHODS: T(1) measurements (1.5 Tesla) were performed in femoral knee cartilage of 23 healthy volunteers. The weight-bearing central cartilage was analyzed before contrast and at eight time points after an intravenous injection of Gd-DTPA(2-) : 12-60 min (4 volunteers) and 1-4 h (19 volunteers). Three regions of interest were segmented manually: deep, middle, and superficial. RESULTS: Before contrast injection, a depth-wise variation of T(1) was observed with 50% higher values in the superficial region compared with the deep region. In the deep region, the uptake of Gd-DTPA(2-) was not detected until 36 min and the concentration increased until 240 min, whereas in the superficial region, the uptake was seen already at 12 min and the concentration decreased after 180 min (P < 0.01). There was a difference between medial and lateral compartment regarding bulk, but not superficial Gd-DTPA(2-) concentration. The bulk gadolinium concentration was negatively related to the cartilage thickness (r = -0.68; P < 0.01). CONCLUSION: The depth-wise and thickness dependent variations in Gd-DTPA(2) transport influence the interpretation of bulk dGEMRIC analysis in vivo. In thick cartilage, incomplete penetration of Gd-DTPA(2) will yield a falsely too long T(1) . J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Magnetic Resonance Imaging
volume
34
pages
1352 - 1358
publisher
John Wiley & Sons
external identifiers
  • wos:000297298800012
  • pmid:21954084
  • scopus:81755183111
ISSN
1522-2586
DOI
10.1002/jmri.22750
language
English
LU publication?
yes
id
5fdd7353-ce2d-4e35-b1fa-0f6cdb6cb0e0 (old id 2168328)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21954084?dopt=Abstract
date added to LUP
2011-10-03 14:41:36
date last changed
2017-09-10 04:47:34
@article{5fdd7353-ce2d-4e35-b1fa-0f6cdb6cb0e0,
  abstract     = {PURPOSE: To investigate the transport of Gd-DTPA(2-) in different layers of femoral knee cartilage in vivo. MATERIALS AND METHODS: T(1) measurements (1.5 Tesla) were performed in femoral knee cartilage of 23 healthy volunteers. The weight-bearing central cartilage was analyzed before contrast and at eight time points after an intravenous injection of Gd-DTPA(2-) : 12-60 min (4 volunteers) and 1-4 h (19 volunteers). Three regions of interest were segmented manually: deep, middle, and superficial. RESULTS: Before contrast injection, a depth-wise variation of T(1) was observed with 50% higher values in the superficial region compared with the deep region. In the deep region, the uptake of Gd-DTPA(2-) was not detected until 36 min and the concentration increased until 240 min, whereas in the superficial region, the uptake was seen already at 12 min and the concentration decreased after 180 min (P &lt; 0.01). There was a difference between medial and lateral compartment regarding bulk, but not superficial Gd-DTPA(2-) concentration. The bulk gadolinium concentration was negatively related to the cartilage thickness (r = -0.68; P &lt; 0.01). CONCLUSION: The depth-wise and thickness dependent variations in Gd-DTPA(2) transport influence the interpretation of bulk dGEMRIC analysis in vivo. In thick cartilage, incomplete penetration of Gd-DTPA(2) will yield a falsely too long T(1) . J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.},
  author       = {Hawezi, Zana and Lammentausta, Eveliina and Svensson, Jonas and Dahlberg, Leif and Tiderius, Carl Johan},
  issn         = {1522-2586},
  language     = {eng},
  pages        = {1352--1358},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {In vivo transport of Gd-DTPA(2-) in human knee cartilage assessed by depth-wise dGEMRIC analysis.},
  url          = {http://dx.doi.org/10.1002/jmri.22750},
  volume       = {34},
  year         = {2011},
}