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Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study.

Borné, Yan LU ; Smith, Gustav LU ; Melander, Olle LU ; Hedblad, Bo LU and Engström, Gunnar LU (2011) In European Journal of Heart Failure 13. p.1355-1361
Abstract
AIMS: Red cell distribution width (RDW) has been associated with cardiovascular disease, but the relation to heart failure (HF) is unclear. We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort. METHODS AND RESULTS: Red cell distribution width was measured in 26 784 subjects (aged 45-73 years, 61% women), without history of myocardial infarction (MI), stroke or HF, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of HF was identified from the national Swedish hospital discharge register during a mean follow-up of 15 years and studied in relation to RDW. During follow-up, 773 subjects (55% men) were hospitalized due to HF, of whom 166 had an... (More)
AIMS: Red cell distribution width (RDW) has been associated with cardiovascular disease, but the relation to heart failure (HF) is unclear. We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort. METHODS AND RESULTS: Red cell distribution width was measured in 26 784 subjects (aged 45-73 years, 61% women), without history of myocardial infarction (MI), stroke or HF, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of HF was identified from the national Swedish hospital discharge register during a mean follow-up of 15 years and studied in relation to RDW. During follow-up, 773 subjects (55% men) were hospitalized due to HF, of whom 166 had an MI before or concurrent with the HF. After adjustment for potential confounding factors (including history of coronary revascularization, biological, lifestyle, and socio-economic factors), the hazard ratios (HR) for HF were 1.47 (95% CI: 1.14-1.89) in the top compared with the bottom quartile of RDW (P for trend 0.005), censoring subjects with incident MI before HF. The results were similar when all hospitalized HF cases were included (HR: 1.33, 1.07-1.66), (P for trend 0.020). After additional adjustment for N-terminal pro-B-type natriuretic peptide, cystatin C and high-sensitive C-reactive protein in a randomly selected subcohort (n= 4761), HR was 1.64 (CI: 0.90-3.00) comparing the top vs. bottom quartile of RDW. CONCLUSION: Red cell distribution width was found to be associated with long-term incidence of first hospitalization due to HF among middle-aged subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Heart Failure
volume
13
pages
1355 - 1361
publisher
Elsevier
external identifiers
  • wos:000297272500014
  • pmid:21940730
  • scopus:81855194778
ISSN
1879-0844
DOI
10.1093/eurjhf/hfr127
language
English
LU publication?
yes
id
316c25aa-43f6-415b-9359-75607200c5ec (old id 2168648)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21940730?dopt=Abstract
date added to LUP
2011-10-03 13:08:54
date last changed
2017-10-01 04:55:26
@article{316c25aa-43f6-415b-9359-75607200c5ec,
  abstract     = {AIMS: Red cell distribution width (RDW) has been associated with cardiovascular disease, but the relation to heart failure (HF) is unclear. We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort. METHODS AND RESULTS: Red cell distribution width was measured in 26 784 subjects (aged 45-73 years, 61% women), without history of myocardial infarction (MI), stroke or HF, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of HF was identified from the national Swedish hospital discharge register during a mean follow-up of 15 years and studied in relation to RDW. During follow-up, 773 subjects (55% men) were hospitalized due to HF, of whom 166 had an MI before or concurrent with the HF. After adjustment for potential confounding factors (including history of coronary revascularization, biological, lifestyle, and socio-economic factors), the hazard ratios (HR) for HF were 1.47 (95% CI: 1.14-1.89) in the top compared with the bottom quartile of RDW (P for trend 0.005), censoring subjects with incident MI before HF. The results were similar when all hospitalized HF cases were included (HR: 1.33, 1.07-1.66), (P for trend 0.020). After additional adjustment for N-terminal pro-B-type natriuretic peptide, cystatin C and high-sensitive C-reactive protein in a randomly selected subcohort (n= 4761), HR was 1.64 (CI: 0.90-3.00) comparing the top vs. bottom quartile of RDW. CONCLUSION: Red cell distribution width was found to be associated with long-term incidence of first hospitalization due to HF among middle-aged subjects.},
  author       = {Borné, Yan and Smith, Gustav and Melander, Olle and Hedblad, Bo and Engström, Gunnar},
  issn         = {1879-0844},
  language     = {eng},
  pages        = {1355--1361},
  publisher    = {Elsevier},
  series       = {European Journal of Heart Failure},
  title        = {Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study.},
  url          = {http://dx.doi.org/10.1093/eurjhf/hfr127},
  volume       = {13},
  year         = {2011},
}