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Determinants for malignancy in surgically treated adrenal lesions.

Wright, Lucie; Nordenström, Erik LU and Almquist, Martin LU (2012) In Langenbeck's Archives of Surgery 397. p.217-223
Abstract
PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had... (More)
PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy. (Less)
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Contribution to journal
publication status
published
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in
Langenbeck's Archives of Surgery
volume
397
pages
217 - 223
publisher
Springer
external identifiers
  • wos:000300493600008
  • pmid:21935703
  • scopus:84858861954
ISSN
1435-2451
DOI
10.1007/s00423-011-0849-9
language
English
LU publication?
yes
id
f8cb93bb-c374-4712-8fa8-a421aaaa6869 (old id 2168705)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21935703?dopt=Abstract
date added to LUP
2011-10-03 11:46:30
date last changed
2017-01-01 07:41:51
@article{f8cb93bb-c374-4712-8fa8-a421aaaa6869,
  abstract     = {PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy.},
  author       = {Wright, Lucie and Nordenström, Erik and Almquist, Martin},
  issn         = {1435-2451},
  language     = {eng},
  pages        = {217--223},
  publisher    = {Springer},
  series       = {Langenbeck's Archives of Surgery},
  title        = {Determinants for malignancy in surgically treated adrenal lesions.},
  url          = {http://dx.doi.org/10.1007/s00423-011-0849-9},
  volume       = {397},
  year         = {2012},
}