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A prospective, population-based study of 40000 women regarding host factors, UV exposure and sunbed use in relation to risk and anatomic site of cutaneous melanoma.

Nielsen, Kari LU ; Måsbäck, Anna; Olsson, Håkan LU and Ingvar, Christian LU (2012) In International Journal of Cancer 131(3). p.706-715
Abstract
Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox regression [SCR], hazard ratios [HRs] with 95 % Confidence Intervals [CI]) in relation to risk factors, age groups (older or younger than 40 years) and primary site, were analysed. In 29520 women with complete follow-up through 2007, 155 invasive and 60 in situ CM were recorded. High numbers of nevi (HR, 2.9; 95% CI, 1.7-5.0) and heredity (HR, 3.7; 95% CI, 2.0-6.8) were associated with risk for CM. SCR analysis added red hair as a... (More)
Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox regression [SCR], hazard ratios [HRs] with 95 % Confidence Intervals [CI]) in relation to risk factors, age groups (older or younger than 40 years) and primary site, were analysed. In 29520 women with complete follow-up through 2007, 155 invasive and 60 in situ CM were recorded. High numbers of nevi (HR, 2.9; 95% CI, 1.7-5.0) and heredity (HR, 3.7; 95% CI, 2.0-6.8) were associated with risk for CM. SCR analysis added red hair as a risk factor. Sunbed use >10 times/year increased risk for women <40 y (HR, 2.5; 95% CI, 1.0-6.2) and a trend for risk associated with sunbathing vacations (HR, 1.4; 95% CI, 1.0-2.0) was shown for women >40 y. Trunk melanoma showed correlations with high numbers of nevi (HR, 3.0; 95% CI, 1.2-7.3) and heredity (HR, 3.2; 95% CI, 1.1-9.4). Head/neck site was correlated to sunbathing vacations (HR, 2.5; 95% CI, 1.2-5.3) and heredity (HR, 7.6; 95% CI, 1.8-31.8). Our study supports divergent etiologic pathways to CM, with high numbers of nevi correlated to increased risk for trunk CM. Furthermore, it confirms that high numbers of nevi, red hair and heredity for CM are the most important risk factors and frequent sunbed use might be a risk factor for younger women. © 2011 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nevus, sunbed, risk factors, prospective, melanoma
in
International Journal of Cancer
volume
131
issue
3
pages
706 - 715
publisher
John Wiley & Sons
external identifiers
  • wos:000304440100037
  • pmid:21898390
  • scopus:84861577155
ISSN
0020-7136
DOI
10.1002/ijc.26408
language
English
LU publication?
yes
id
c0883eb1-b5d5-4142-a022-658d08e4a19b (old id 2169082)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21898390?dopt=Abstract
date added to LUP
2011-10-03 09:51:11
date last changed
2017-07-23 03:26:33
@article{c0883eb1-b5d5-4142-a022-658d08e4a19b,
  abstract     = {Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox regression [SCR], hazard ratios [HRs] with 95 % Confidence Intervals [CI]) in relation to risk factors, age groups (older or younger than 40 years) and primary site, were analysed. In 29520 women with complete follow-up through 2007, 155 invasive and 60 in situ CM were recorded. High numbers of nevi (HR, 2.9; 95% CI, 1.7-5.0) and heredity (HR, 3.7; 95% CI, 2.0-6.8) were associated with risk for CM. SCR analysis added red hair as a risk factor. Sunbed use &gt;10 times/year increased risk for women &lt;40 y (HR, 2.5; 95% CI, 1.0-6.2) and a trend for risk associated with sunbathing vacations (HR, 1.4; 95% CI, 1.0-2.0) was shown for women &gt;40 y. Trunk melanoma showed correlations with high numbers of nevi (HR, 3.0; 95% CI, 1.2-7.3) and heredity (HR, 3.2; 95% CI, 1.1-9.4). Head/neck site was correlated to sunbathing vacations (HR, 2.5; 95% CI, 1.2-5.3) and heredity (HR, 7.6; 95% CI, 1.8-31.8). Our study supports divergent etiologic pathways to CM, with high numbers of nevi correlated to increased risk for trunk CM. Furthermore, it confirms that high numbers of nevi, red hair and heredity for CM are the most important risk factors and frequent sunbed use might be a risk factor for younger women. © 2011 Wiley-Liss, Inc.},
  author       = {Nielsen, Kari and Måsbäck, Anna and Olsson, Håkan and Ingvar, Christian},
  issn         = {0020-7136},
  keyword      = {nevus,sunbed,risk factors,prospective,melanoma},
  language     = {eng},
  number       = {3},
  pages        = {706--715},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {A prospective, population-based study of 40000 women regarding host factors, UV exposure and sunbed use in relation to risk and anatomic site of cutaneous melanoma.},
  url          = {http://dx.doi.org/10.1002/ijc.26408},
  volume       = {131},
  year         = {2012},
}