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Initial Results of Inflammatory Response, Matrix Remodeling, and Reactive Oxygen Species Following PCI in Acute Ischemic Myocardial Injury in Man.

Hedström, Erik LU ; Åström-Olsson, Karin; Öhlin, Ann-Kristin LU ; Öhlin, Hans and Arheden, Håkan LU (2011) In The Journal of Invasive Cardiology 23(9). p.371-376
Abstract
BACKGROUND:

Neutrophils and reactive oxygen species (ROS) are suggested to be involved in irreversible myocardial reperfusion injury and stunning. We investigated the relations between circulating biochemical markers and myocardium at risk (MaR), myocardial infarct (MI) size, salvage, and recovery of function in man.



METHODS AND RESULTS:

In patients undergoing PCI serial blood samples were acquired for markers of inflammatory response (myeloperoxidase [MPO], neutrophil-gelatinase-associated lipocalin [NGAL], interleukins 6 and 8 [IL-6/8], tumor necrosis factor-a [TNF-a], high-sensitive C-reactive protein [hsCRP]), matrix remodeling (matrixmetalloproteinase-9 [MMP-9]) and ROS (malondialdehyde [MDA],... (More)
BACKGROUND:

Neutrophils and reactive oxygen species (ROS) are suggested to be involved in irreversible myocardial reperfusion injury and stunning. We investigated the relations between circulating biochemical markers and myocardium at risk (MaR), myocardial infarct (MI) size, salvage, and recovery of function in man.



METHODS AND RESULTS:

In patients undergoing PCI serial blood samples were acquired for markers of inflammatory response (myeloperoxidase [MPO], neutrophil-gelatinase-associated lipocalin [NGAL], interleukins 6 and 8 [IL-6/8], tumor necrosis factor-a [TNF-a], high-sensitive C-reactive protein [hsCRP]), matrix remodeling (matrixmetalloproteinase-9 [MMP-9]) and ROS (malondialdehyde [MDA], isoprostane [IsoP]). Samples were obtained before PCI and 1.5, 3, and 24 hours after reperfusion. Myocardial perfusion SPECT (MPS) was used to assess MaR. Late gadolinum-enhanced cardiac magnetic resonance imaging was performed for regional function in the acute setting, at 1 week and 6 months, and at 1 week also for MI size. Sixteen patients (15 men; 42-78 years) were enrolled, 12 of whom underwent MPS. Peak and cumulative NGAL and cumulative MMP-9 showed inverse correlations to MaR. No correlation was found for MI size. Peak MPO correlated inversely to salvage and to recovery of regional function in the infarcted segments at 1 week and 6 months.



CONCLUSIONS:

This is the first study in man to show inverse relations between circulating NGAL and MMP-9 and MaR. The current results do not support that ROS has a role in stunning in man. MI size showed no significant correlation to any parameter, challenging inflammatory treatment in repercussion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Invasive Cardiology
volume
23
issue
9
pages
371 - 376
publisher
HMP Communications
external identifiers
  • wos:000294973400008
  • pmid:21891809
  • scopus:80855124038
ISSN
1042-3931
language
English
LU publication?
yes
id
b1bcfb57-c67c-4793-9834-8b8dcd7736e4 (old id 2169141)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21891809?dopt=Abstract
date added to LUP
2011-10-03 09:32:19
date last changed
2017-08-06 04:47:13
@article{b1bcfb57-c67c-4793-9834-8b8dcd7736e4,
  abstract     = {BACKGROUND:<br/><br>
Neutrophils and reactive oxygen species (ROS) are suggested to be involved in irreversible myocardial reperfusion injury and stunning. We investigated the relations between circulating biochemical markers and myocardium at risk (MaR), myocardial infarct (MI) size, salvage, and recovery of function in man.<br/><br>
<br/><br>
METHODS AND RESULTS:<br/><br>
In patients undergoing PCI serial blood samples were acquired for markers of inflammatory response (myeloperoxidase [MPO], neutrophil-gelatinase-associated lipocalin [NGAL], interleukins 6 and 8 [IL-6/8], tumor necrosis factor-a [TNF-a], high-sensitive C-reactive protein [hsCRP]), matrix remodeling (matrixmetalloproteinase-9 [MMP-9]) and ROS (malondialdehyde [MDA], isoprostane [IsoP]). Samples were obtained before PCI and 1.5, 3, and 24 hours after reperfusion. Myocardial perfusion SPECT (MPS) was used to assess MaR. Late gadolinum-enhanced cardiac magnetic resonance imaging was performed for regional function in the acute setting, at 1 week and 6 months, and at 1 week also for MI size. Sixteen patients (15 men; 42-78 years) were enrolled, 12 of whom underwent MPS. Peak and cumulative NGAL and cumulative MMP-9 showed inverse correlations to MaR. No correlation was found for MI size. Peak MPO correlated inversely to salvage and to recovery of regional function in the infarcted segments at 1 week and 6 months.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
This is the first study in man to show inverse relations between circulating NGAL and MMP-9 and MaR. The current results do not support that ROS has a role in stunning in man. MI size showed no significant correlation to any parameter, challenging inflammatory treatment in repercussion.},
  author       = {Hedström, Erik and Åström-Olsson, Karin and Öhlin, Ann-Kristin and Öhlin, Hans and Arheden, Håkan},
  issn         = {1042-3931},
  language     = {eng},
  number       = {9},
  pages        = {371--376},
  publisher    = {HMP Communications},
  series       = {The Journal of Invasive Cardiology},
  title        = {Initial Results of Inflammatory Response, Matrix Remodeling, and Reactive Oxygen Species Following PCI in Acute Ischemic Myocardial Injury in Man.},
  volume       = {23},
  year         = {2011},
}