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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Wain, Louise V.; Verwoert, Germaine C.; O'Reilly, Paul F.; Shi, Gang; Johnson, Toby; Johnson, Andrew D.; Bochud, Murielle; Rice, Kenneth M.; Henneman, Peter and Smith, Albert V., et al. (2011) In Nature Genetics 43(10). p.122-1005
Abstract
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of... (More)
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. (Less)
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Nature Genetics
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43
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10
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122 - 1005
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Nature Publishing Group
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  • scopus:80053383403
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1546-1718
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10.1038/ng.922
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English
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@article{2c9cfbd8-1731-4ef7-8ae6-dd5e46c528a2,
  abstract     = {Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.},
  author       = {Wain, Louise V. and Verwoert, Germaine C. and O'Reilly, Paul F. and Shi, Gang and Johnson, Toby and Johnson, Andrew D. and Bochud, Murielle and Rice, Kenneth M. and Henneman, Peter and Smith, Albert V. and Ehret, Georg B. and Amin, Najaf and Larson, Martin G. and Mooser, Vincent and Hadley, David and Doerr, Marcus and Bis, Joshua C. and Aspelund, Thor and Esko, Tonu and Janssens, A. Cecile J. W. and Zhao, Jing Hua and Heath, Simon and Laan, Maris and Fu, Jingyuan and Pistis, Giorgio and Luan, Jian'an and Arora, Pankaj and Lucas, Gavin and Pirastu, Nicola and Pichler, Irene and Jackson, Anne U. and Webster, Rebecca J. and Zhang, Feng and Peden, John F. and Schmidt, Helena and Tanaka, Toshiko and Campbell, Harry and Igl, Wilmar and Milaneschi, Yuri and Hottenga, Jouke-Jan and Vitart, Veronique and Chasman, Daniel I. and Trompet, Stella and Bragg-Gresham, Jennifer L. and Alizadeh, Behrooz Z. and Chambers, John C. and Guo, Xiuqing and Lehtimaki, Terho and Kuehnel, Brigitte and Lopez, Lorna M. and Polasek, Ozren and Boban, Mladen and Nelson, Christopher P. and Morrison, Alanna C. and Pihur, Vasyl and Ganesh, Santhi K. and Hofman, Albert and Kundu, Suman and Mattace-Raso, Francesco U. S. and Rivadeneira, Fernando and Sijbrands, Eric J. G. and Uitterlinden, Andre G. and Hwang, Shih-Jen and Vasan, Ramachandran S. and Wang, Thomas J. and Bergmann, Sven and Vollenweider, Peter and Waeber, Gerard and Laitinen, Jaana and Pouta, Anneli and Zitting, Paavo and McArdle, Wendy L. and Kroemer, Heyo K. and Voelker, Uwe and Voelzke, Henry and Glazer, Nicole L. and Taylor, Kent D. and Harris, Tamara B. and Alavere, Helene and Haller, Toomas and Keis, Aime and Tammesoo, Mari-Liis and Aulchenko, Yurii and Barroso, Ines and Khaw, Kay-Tee and Galan, Pilar and Hercberg, Serge and Lathrop, Mark and Eyheramendy, Susana and Org, Elin and Sober, Siim and Lu, Xiaowen and Nolte, Ilja M. and Penninx, Brenda W. and Corre, Tanguy and Masciullo, Corrado and Sala, Cinzia and Groop, Leif and Voight, Benjamin F. and Melander, Olle and O'Donnell, Christopher J. and Salomaa, Veikko and d'Adamo, Adamo Pio and Fabretto, Antonella and Faletra, Flavio and Ulivi, Sheila and Del Greco, Fabiola M. and Facheris, Maurizio and Collins, Francis S. and Bergman, Richard N. and Beilby, John P. and Hung, Joseph and Musk, A. William and Mangino, Massimo and Shin, So-Youn and Soranzo, Nicole and Watkins, Hugh and Goel, Anuj and Hamsten, Anders and Gider, Pierre and Loitfelder, Marisa and Zeginigg, Marion and Hernandez, Dena and Najjar, Samer S. and Navarro, Pau and Wild, Sarah H. and Corsi, Anna Maria and Singleton, Andrew and de Geus, Eco J. C. and Willemsen, Gonneke and Parker, Alex N. and Rose, Lynda M. and Buckley, Brendan and Stott, David and Orru, Marco and Uda, Manuela and van der Klauw, Melanie M. and Zhang, Weihua and Li, Xinzhong and Scott, James and Chen, Yii-Der Ida and Burke, Gregory L. and Kahonen, Mika and Viikari, Jorma and Doering, Angela and Meitinger, Thomas and Davies, Gail and Starr, John M. and Emilsson, Valur and Plump, Andrew and Lindeman, Jan H. and 't Hoen, Peter A. C. and Koenig, Inke R. and Felix, Janine F. and Clarke, Robert and Hopewell, Jemma C. and Ongen, Halit and Breteler, Monique and Debette, Stephanie and DeStefano, Anita L. and Fornage, Myriam and Mitchell, Gary F. and Smith, Nicholas L. and Holm, Hilma and Stefansson, Kari and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Samani, Nilesh J. and Preuss, Michael and Rudan, Igor and Hayward, Caroline and Deary, Ian J. and Wichmann, H-Erich and Raitakari, Olli T. and Palmas, Walter and Kooner, Jaspal S. and Stolk, Ronald P. and Jukema, J. Wouter and Wright, Alan F. and Boomsma, Dorret I. and Bandinelli, Stefania and Gyllensten, Ulf B. and Wilson, James F. and Ferrucci, Luigi and Schmidt, Reinhold and Farrall, Martin and Spector, Tim D. and Palmer, Lyle J. and Tuomilehto, Jaakko and Pfeufer, Arne and Gasparini, Paolo and Siscovick, David and Altshuler, David and Loos, Ruth J. F. and Toniolo, Daniela and Snieder, Harold and Gieger, Christian and Meneton, Pierre and Wareham, Nicholas J. and Oostra, Ben A. and Metspalu, Andres and Launer, Lenore and Rettig, Rainer and Strachan, David P. and Beckmann, Jacques S. and Witteman, Jacqueline C. M. and Erdmann, Jeanette and van Dijk, Ko Willems and Boerwinkle, Eric and Boehnke, Michael and Ridker, Paul M. and Jarvelin, Marjo-Riitta and Chakravarti, Aravinda and Abecasis, Goncalo R. and Gudnason, Vilmundur and Newton-Cheh, Christopher and Levy, Daniel and Munroe, Patricia B. and Psaty, Bruce M. and Caulfield, Mark J. and Rao, Dabeeru C. and Tobin, Martin D. and Elliott, Paul and van Duijn, Cornelia M.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {10},
  pages        = {122--1005},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure},
  url          = {http://dx.doi.org/10.1038/ng.922},
  volume       = {43},
  year         = {2011},
}