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A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Chuang, Shu-Chun; Stolzenberg-Solomon, Rachael; Ueland, Per Magne; Vollset, Stein Emil; Midttun, Oivind; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Boutron-Ruault, Marie-Christine and Morois, Sophie, et al. (2011) In European Journal of Cancer 47(12). p.1808-1816
Abstract
Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (+/- 1 year), date (+/- 1 year) and time (+/- 3 h) at blood collection and fasting status. Conditional logistic... (More)
Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (+/- 1 year), date (+/- 1 year) and time (+/- 3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate <= 5, 5-10, 10-15 (reference), 15-20, and > 20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity < 0.01). Our results suggest a U-shaped association between plasma folate and pancreatic cancer risk in both men and women. The positive association that we observed between methionine and pancreatic cancer may be sex dependent and may differ by time of follow-up. However, the mechanisms behind the observed associations warrant further investigation. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
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published
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keywords
Folate, One-carbon metabolism, Pancreatic cancer, EPIC
in
European Journal of Cancer
volume
47
issue
12
pages
1808 - 1816
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000295070900007
  • scopus:80051551995
ISSN
1879-0852
DOI
10.1016/j.ejca.2011.02.007
language
English
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yes
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83d8750f-3505-43e4-b551-a3c196b80006 (old id 2179906)
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2011-11-01 07:48:43
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2017-10-29 03:06:59
@article{83d8750f-3505-43e4-b551-a3c196b80006,
  abstract     = {Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (+/- 1 year), date (+/- 1 year) and time (+/- 3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate &lt;= 5, 5-10, 10-15 (reference), 15-20, and &gt; 20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity &lt; 0.01). Our results suggest a U-shaped association between plasma folate and pancreatic cancer risk in both men and women. The positive association that we observed between methionine and pancreatic cancer may be sex dependent and may differ by time of follow-up. However, the mechanisms behind the observed associations warrant further investigation. (C) 2011 Elsevier Ltd. All rights reserved.},
  author       = {Chuang, Shu-Chun and Stolzenberg-Solomon, Rachael and Ueland, Per Magne and Vollset, Stein Emil and Midttun, Oivind and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Boutron-Ruault, Marie-Christine and Morois, Sophie and Clavel-Chapelon, Francoise and Teucher, Birgit and Kaaks, Rudolf and Weikert, Cornelia and Boeing, Heiner and Trichopoulou, Antonia and Benetou, Vassiliki and Naska, Androniki and Jenab, Mazda and Slimani, Nadia and Romieu, Isabelle and Michaud, Dominique S. and Palli, Domenico and Sieri, Sabina and Panico, Salvatore and Sacerdote, Carlotta and Tumino, Rosario and Skeie, Guri and Duell, Eric J. and Rodriguez, Laudina and Molina-Montes, Esther and Maria Huerta, Jose and Larranaga, Nerea and Barricarte Gurrea, Aurelio and Johansen, Dorthe and Manjer, Jonas and Ye, Weimin and Sund, Malin and Peeters, Petra H. M. and Jeurnink, Suzanne and Wareham, Nicholas and Khaw, Kay-Tee and Crowe, Francesca and Riboli, Elio and Bueno-de-Mesquita, Bas and Vineis, Paolo},
  issn         = {1879-0852},
  keyword      = {Folate,One-carbon metabolism,Pancreatic cancer,EPIC},
  language     = {eng},
  number       = {12},
  pages        = {1808--1816},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1016/j.ejca.2011.02.007},
  volume       = {47},
  year         = {2011},
}