Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitis.
(2003) In American Journal of Respiratory and Critical Care Medicine 167(11). p.1504-1508- Abstract
- Secretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before and during natural allergen exposure. Immunohistochemical analysis revealed an abundance of nerves displaying secretoneurin immunoreactivity, which were distributed predominantly around blood vessels and submucosal glands. A majority of nerve fibers containing vesicular acetylcholine transporter, tyrosine hydroxylase, calcitonin gene–related... (More)
- Secretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before and during natural allergen exposure. Immunohistochemical analysis revealed an abundance of nerves displaying secretoneurin immunoreactivity, which were distributed predominantly around blood vessels and submucosal glands. A majority of nerve fibers containing vesicular acetylcholine transporter, tyrosine hydroxylase, calcitonin gene–related peptide, and vasoactive intestinal peptide were also secretoneurin-immunoreactive, indicating a localization of secretoneurin in cholinergic, adrenergic, and sensory nerves. Lavage fluid levels of secretoneurin were increased at allergen exposure (p < 0.01–0.05). Levels of secretoneurin did not correlate with eosinophil cationic protein ({rho} = 0.1, p = 0.7). We conclude that secretoneurin has a widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure. These data favor a role of secretoneurin in the local traffic of immune cells in human airway mucosa. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/112915
- author
- Korsgren, Magnus LU ; Erjefalt, Jonas S ; Hinterholzl, Josef ; Fischer-Colbrie, Reiner ; Ahlstrom Emanuelsson, Cecilia ; Andersson, Morgan ; Persson, Carl LU ; Mackay-Sim, Alan ; Sundler, Frank LU and Greiff, Lennart LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic airway inflammation, neuropeptides, eosinophils
- in
- American Journal of Respiratory and Critical Care Medicine
- volume
- 167
- issue
- 11
- pages
- 1504 - 1508
- publisher
- American Thoracic Society
- external identifiers
-
- wos:000183078300011
- pmid:12626352
- scopus:0037794409
- ISSN
- 1535-4970
- DOI
- 10.1164/rccm.200212-1508OC
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Division of Clinical Chemistry and Pharmacology (013250300), Otorhinolaryngology (Lund) (013044000)
- id
- 217a57e4-32ee-48dc-b7cb-7f21b0ace4b3 (old id 112915)
- date added to LUP
- 2016-04-01 11:51:54
- date last changed
- 2022-01-26 19:20:33
@article{217a57e4-32ee-48dc-b7cb-7f21b0ace4b3,
abstract = {{Secretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before and during natural allergen exposure. Immunohistochemical analysis revealed an abundance of nerves displaying secretoneurin immunoreactivity, which were distributed predominantly around blood vessels and submucosal glands. A majority of nerve fibers containing vesicular acetylcholine transporter, tyrosine hydroxylase, calcitonin gene–related peptide, and vasoactive intestinal peptide were also secretoneurin-immunoreactive, indicating a localization of secretoneurin in cholinergic, adrenergic, and sensory nerves. Lavage fluid levels of secretoneurin were increased at allergen exposure (p < 0.01–0.05). Levels of secretoneurin did not correlate with eosinophil cationic protein ({rho} = 0.1, p = 0.7). We conclude that secretoneurin has a widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure. These data favor a role of secretoneurin in the local traffic of immune cells in human airway mucosa.}},
author = {{Korsgren, Magnus and Erjefalt, Jonas S and Hinterholzl, Josef and Fischer-Colbrie, Reiner and Ahlstrom Emanuelsson, Cecilia and Andersson, Morgan and Persson, Carl and Mackay-Sim, Alan and Sundler, Frank and Greiff, Lennart}},
issn = {{1535-4970}},
keywords = {{allergic airway inflammation; neuropeptides; eosinophils}},
language = {{eng}},
number = {{11}},
pages = {{1504--1508}},
publisher = {{American Thoracic Society}},
series = {{American Journal of Respiratory and Critical Care Medicine}},
title = {{Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitis.}},
url = {{http://dx.doi.org/10.1164/rccm.200212-1508OC}},
doi = {{10.1164/rccm.200212-1508OC}},
volume = {{167}},
year = {{2003}},
}