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Reduced corneal nerve fiber density in type 2 diabetes by wide-area mosaic analysis

Lagali, Neil S.; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza A.; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus and Dahlin, Lars B. LU , et al. (2017) In Investigative Ophthalmology and Visual Science 58(14). p.6318-6327
Abstract

PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from widearea depth-corrected mosaic images are associated with type 2 diabetes. METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laserscanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration < 10 years and long duration ≥ 10 years). RESULTS. In mosaics with a mean size of 6 mm2 in subjects aged 69.1 ± 1.2 years, mCNFL in type 2 diabetes was... (More)

PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from widearea depth-corrected mosaic images are associated with type 2 diabetes. METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laserscanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration < 10 years and long duration ≥ 10 years). RESULTS. In mosaics with a mean size of 6 mm2 in subjects aged 69.1 ± 1.2 years, mCNFL in type 2 diabetes was reduced relative to nondiabetic subjects (13.1 ± 4.2 vs. 15.0 ± 3.2 mm/mm2, P = 0.018). Also reduced relative to nondiabetic subjects was mCNFL in both shortduration (14.0 ± 4.0 mm/mm2, 3.2 ± 3.9 years since diagnosis) and long-duration diabetes (12.7 ± 4.2 mm/mm2, 15.4 ± 4.2 years since diagnosis; ANOVA P = 0.023). Lower mCNFL was associated with presence of diabetes (P = 0.032) and increased hemoglobin A1c (HbA1c) levels (P = 0.047). By contrast, wCNFL was unaffected by diabetes or HbA1c (P > 0.05). Global SBP patterns revealed marked degeneration of secondary nerve fiber branches outside the whorl region in long-duration diabetes. CONCLUSIONS. Wide-area mosaic images provide reference values for mCNFL and wCNFL and reveal a progressive degeneration of the SBP with increasing duration of type 2 diabetes

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Contribution to journal
publication status
published
subject
keywords
Confocal microscopy, Corneal nerves, Diabetes mellitus, Subbasal nerve
in
Investigative Ophthalmology and Visual Science
volume
58
issue
14
pages
10 pages
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • scopus:85038358323
ISSN
0146-0404
DOI
10.1167/iovs.17-22257
language
English
LU publication?
yes
id
217ec718-3057-481f-b0e1-6a209dbbec8a
date added to LUP
2018-01-11 14:38:26
date last changed
2018-10-07 05:03:52
@article{217ec718-3057-481f-b0e1-6a209dbbec8a,
  abstract     = {<p>PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from widearea depth-corrected mosaic images are associated with type 2 diabetes. METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laserscanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration &lt; 10 years and long duration ≥ 10 years). RESULTS. In mosaics with a mean size of 6 mm<sup>2</sup> in subjects aged 69.1 ± 1.2 years, mCNFL in type 2 diabetes was reduced relative to nondiabetic subjects (13.1 ± 4.2 vs. 15.0 ± 3.2 mm/mm<sup>2</sup>, P = 0.018). Also reduced relative to nondiabetic subjects was mCNFL in both shortduration (14.0 ± 4.0 mm/mm<sup>2</sup>, 3.2 ± 3.9 years since diagnosis) and long-duration diabetes (12.7 ± 4.2 mm/mm<sup>2</sup>, 15.4 ± 4.2 years since diagnosis; ANOVA P = 0.023). Lower mCNFL was associated with presence of diabetes (P = 0.032) and increased hemoglobin A1c (HbA1c) levels (P = 0.047). By contrast, wCNFL was unaffected by diabetes or HbA1c (P &gt; 0.05). Global SBP patterns revealed marked degeneration of secondary nerve fiber branches outside the whorl region in long-duration diabetes. CONCLUSIONS. Wide-area mosaic images provide reference values for mCNFL and wCNFL and reveal a progressive degeneration of the SBP with increasing duration of type 2 diabetes</p>},
  author       = {Lagali, Neil S. and Allgeier, Stephan and Guimarães, Pedro and Badian, Reza A. and Ruggeri, Alfredo and Köhler, Bernd and Utheim, Tor Paaske and Peebo, Beatrice and Peterson, Magnus and Dahlin, Lars B. and Rolandsson, Olov},
  issn         = {0146-0404},
  keyword      = {Confocal microscopy,Corneal nerves,Diabetes mellitus,Subbasal nerve},
  language     = {eng},
  month        = {12},
  number       = {14},
  pages        = {6318--6327},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology and Visual Science},
  title        = {Reduced corneal nerve fiber density in type 2 diabetes by wide-area mosaic analysis},
  url          = {http://dx.doi.org/10.1167/iovs.17-22257},
  volume       = {58},
  year         = {2017},
}