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MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions

Dewey, B E ; Xu, X LU ; Knutsson, L LU orcid ; Jog, A ; Prince, J L ; Barker, P B ; van Zijl, P C M ; Leigh, R and Nyquist, P (2021) In AJNR. American journal of neuroradiology 42(8). p.1396-1402
Abstract

BACKGROUND AND PURPOSE: White matter lesions of presumed ischemic origin are associated with progressive cognitive impairment and impaired BBB function. Studying the longitudinal effects of white matter lesion biomarkers that measure changes in perfusion and BBB patency within white matter lesions is required for long-term studies of lesion progression. We studied perfusion and BBB disruption within white matter lesions in asymptomatic subjects.

MATERIALS AND METHODS: Anatomic imaging was followed by consecutive dynamic contrast-enhanced and DSC imaging. White matter lesions in 21 asymptomatic individuals were determined using a Subject-Specific Sparse Dictionary Learning algorithm with manual correction. Perfusion-related... (More)

BACKGROUND AND PURPOSE: White matter lesions of presumed ischemic origin are associated with progressive cognitive impairment and impaired BBB function. Studying the longitudinal effects of white matter lesion biomarkers that measure changes in perfusion and BBB patency within white matter lesions is required for long-term studies of lesion progression. We studied perfusion and BBB disruption within white matter lesions in asymptomatic subjects.

MATERIALS AND METHODS: Anatomic imaging was followed by consecutive dynamic contrast-enhanced and DSC imaging. White matter lesions in 21 asymptomatic individuals were determined using a Subject-Specific Sparse Dictionary Learning algorithm with manual correction. Perfusion-related parameters including CBF, MTT, the BBB leakage parameter, and volume transfer constant were determined.

RESULTS: MTT was significantly prolonged (7.88 [SD, 1.03] seconds) within white matter lesions compared with normal-appearing white (7.29 [SD, 1.14] seconds) and gray matter (6.67 [SD, 1.35] seconds). The volume transfer constant, measured by dynamic contrast-enhanced imaging, was significantly elevated (0.013 [SD, 0.017] minutes-1) in white matter lesions compared with normal-appearing white matter (0.007 [SD, 0.011]  minutes-1). BBB disruption within white matter lesions was detected relative to normal white and gray matter using the DSC-BBB leakage parameter method so that increasing BBB disruption correlated with increasing white matter lesion volume (Spearman correlation coefficient = 0.44; P < .046).

CONCLUSIONS: A dual-contrast-injection MR imaging protocol combined with a 3D automated segmentation analysis pipeline was used to assess BBB disruption in white matter lesions on the basis of quantitative perfusion measures including the volume transfer constant (dynamic contrast-enhanced imaging), the BBB leakage parameter (DSC), and MTT (DSC). This protocol was able to detect early pathologic changes in otherwise healthy individuals.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AJNR. American journal of neuroradiology
volume
42
issue
8
pages
1396 - 1402
publisher
American Society of Neuroradiology
external identifiers
  • scopus:85112738623
  • pmid:34083262
ISSN
1936-959X
DOI
10.3174/ajnr.A7165
project
Optimisation and Validation of Dynamic Susceptibility Contrast MRI
language
English
LU publication?
yes
id
21a1fc60-448f-4c02-898e-0983ae6fa9a0
date added to LUP
2021-06-09 22:48:30
date last changed
2024-02-20 08:16:54
@article{21a1fc60-448f-4c02-898e-0983ae6fa9a0,
  abstract     = {{<p>BACKGROUND AND PURPOSE: White matter lesions of presumed ischemic origin are associated with progressive cognitive impairment and impaired BBB function. Studying the longitudinal effects of white matter lesion biomarkers that measure changes in perfusion and BBB patency within white matter lesions is required for long-term studies of lesion progression. We studied perfusion and BBB disruption within white matter lesions in asymptomatic subjects.</p><p>MATERIALS AND METHODS: Anatomic imaging was followed by consecutive dynamic contrast-enhanced and DSC imaging. White matter lesions in 21 asymptomatic individuals were determined using a Subject-Specific Sparse Dictionary Learning algorithm with manual correction. Perfusion-related parameters including CBF, MTT, the BBB leakage parameter, and volume transfer constant were determined.</p><p>RESULTS: MTT was significantly prolonged (7.88 [SD, 1.03] seconds) within white matter lesions compared with normal-appearing white (7.29 [SD, 1.14] seconds) and gray matter (6.67 [SD, 1.35] seconds). The volume transfer constant, measured by dynamic contrast-enhanced imaging, was significantly elevated (0.013 [SD, 0.017] minutes-1) in white matter lesions compared with normal-appearing white matter (0.007 [SD, 0.011]  minutes-1). BBB disruption within white matter lesions was detected relative to normal white and gray matter using the DSC-BBB leakage parameter method so that increasing BBB disruption correlated with increasing white matter lesion volume (Spearman correlation coefficient = 0.44; P &lt; .046).</p><p>CONCLUSIONS: A dual-contrast-injection MR imaging protocol combined with a 3D automated segmentation analysis pipeline was used to assess BBB disruption in white matter lesions on the basis of quantitative perfusion measures including the volume transfer constant (dynamic contrast-enhanced imaging), the BBB leakage parameter (DSC), and MTT (DSC). This protocol was able to detect early pathologic changes in otherwise healthy individuals.</p>}},
  author       = {{Dewey, B E and Xu, X and Knutsson, L and Jog, A and Prince, J L and Barker, P B and van Zijl, P C M and Leigh, R and Nyquist, P}},
  issn         = {{1936-959X}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{8}},
  pages        = {{1396--1402}},
  publisher    = {{American Society of Neuroradiology}},
  series       = {{AJNR. American journal of neuroradiology}},
  title        = {{MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions}},
  url          = {{http://dx.doi.org/10.3174/ajnr.A7165}},
  doi          = {{10.3174/ajnr.A7165}},
  volume       = {{42}},
  year         = {{2021}},
}