Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis
(2005) In Modern Pathology 18(8). p.1113-1120- Abstract
- Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive... (More)
- Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive staining for bcl-6 or CD10 predicted for superior survival, while expression of IRF-4 alone showed no association with prognosis. Furthermore, expression of bcl-2 was associated with worse event-free survival and overall survival. In a multivariate analysis, a high international prognostic index score ( 3 - 5), non-GC phenotype and bcl-2 were independent adverse prognostic factors. Here we confirm the prognostic importance of determining the germinal- or nongerminal center phenotype in patients with DLBCL. (Less)
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https://lup.lub.lu.se/record/232280
- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- lymphoma, germinal center, prognosis
- in
- Modern Pathology
- volume
- 18
- issue
- 8
- pages
- 1113 - 1120
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000230646000014
- pmid:15920553
- scopus:24044473086
- ISSN
- 1530-0285
- DOI
- 10.1038/modpathol.3800396
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- 21a73151-f955-4d63-bc76-913cf55f0156 (old id 232280)
- date added to LUP
- 2016-04-01 16:14:28
- date last changed
- 2022-04-15 03:05:16
@article{21a73151-f955-4d63-bc76-913cf55f0156, abstract = {{Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive staining for bcl-6 or CD10 predicted for superior survival, while expression of IRF-4 alone showed no association with prognosis. Furthermore, expression of bcl-2 was associated with worse event-free survival and overall survival. In a multivariate analysis, a high international prognostic index score ( 3 - 5), non-GC phenotype and bcl-2 were independent adverse prognostic factors. Here we confirm the prognostic importance of determining the germinal- or nongerminal center phenotype in patients with DLBCL.}}, author = {{Berglund, M and Thunberg, U and Amini, RM and Book, M and Roos, G and Erlanson, M and Linderoth, Johan and Dictor, Michael and Jerkeman, Mats and Cavallin-Ståhl, Eva and Sundstrom, C and Rehn-Eriksson, S and Backlin, C and Hagberg, H and Rosenquist, R and Enblad, G}}, issn = {{1530-0285}}, keywords = {{lymphoma; germinal center; prognosis}}, language = {{eng}}, number = {{8}}, pages = {{1113--1120}}, publisher = {{Nature Publishing Group}}, series = {{Modern Pathology}}, title = {{Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis}}, url = {{http://dx.doi.org/10.1038/modpathol.3800396}}, doi = {{10.1038/modpathol.3800396}}, volume = {{18}}, year = {{2005}}, }