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Effect of hydrophobic modifications in antimicrobial peptides.

Schmidtchen, Artur LU ; Pasupuleti, Mukesh LU and Malmsten, Martin (2013) In Advances in Colloid and Interface Science
Abstract
With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with the long-term aim of developing these to potent and safe therapeutics. In the present overview, focus is placed on hydrophobic modifications of antimicrobial peptides, and how these may provide opportunities to combat also more demanding pathogens, including multi-resistant strains, yet not provoking unacceptable toxic responses. In doing so, physicochemical factors affecting peptide... (More)
With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with the long-term aim of developing these to potent and safe therapeutics. In the present overview, focus is placed on hydrophobic modifications of antimicrobial peptides, and how these may provide opportunities to combat also more demanding pathogens, including multi-resistant strains, yet not provoking unacceptable toxic responses. In doing so, physicochemical factors affecting peptide interactions with bacterial and eukaryotic cell membranes are discussed. Throughout, an attempt is made to illustrate how physicochemical studies on model lipid membranes can be correlated to result from bacterial and cell assays, and knowledge from this translated into therapeutic considerations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advances in Colloid and Interface Science
publisher
Elsevier
external identifiers
  • pmid:23910480
  • wos:000333780600020
  • scopus:84903362494
ISSN
1873-3727
DOI
10.1016/j.cis.2013.06.009
language
English
LU publication?
yes
id
21f31a83-7c7d-4b79-892b-2e06fc34f0cf (old id 4006234)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23910480?dopt=Abstract
date added to LUP
2013-09-03 13:26:00
date last changed
2019-10-15 04:24:17
@article{21f31a83-7c7d-4b79-892b-2e06fc34f0cf,
  abstract     = {With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with the long-term aim of developing these to potent and safe therapeutics. In the present overview, focus is placed on hydrophobic modifications of antimicrobial peptides, and how these may provide opportunities to combat also more demanding pathogens, including multi-resistant strains, yet not provoking unacceptable toxic responses. In doing so, physicochemical factors affecting peptide interactions with bacterial and eukaryotic cell membranes are discussed. Throughout, an attempt is made to illustrate how physicochemical studies on model lipid membranes can be correlated to result from bacterial and cell assays, and knowledge from this translated into therapeutic considerations.},
  author       = {Schmidtchen, Artur and Pasupuleti, Mukesh and Malmsten, Martin},
  issn         = {1873-3727},
  language     = {eng},
  month        = {07},
  publisher    = {Elsevier},
  series       = {Advances in Colloid and Interface Science},
  title        = {Effect of hydrophobic modifications in antimicrobial peptides.},
  url          = {http://dx.doi.org/10.1016/j.cis.2013.06.009},
  year         = {2013},
}