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Risk of coronary heart disease in patients with cancer: A nationwide follow-up study from Sweden.

Zöller, Bengt LU ; Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2012) In European Journal of Cancer 48. p.121-128
Abstract
BACKGROUND: Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD. METHODS: All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for CHD were calculated. RESULTS: The overall CHD risk during the first 6months after diagnosis of cancer was 1.70 (95% confidence interval (95% CI) 1.66-1.75). For 26 of the 34 cancers studied, the risk of CHD was increased during the first... (More)
BACKGROUND: Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD. METHODS: All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for CHD were calculated. RESULTS: The overall CHD risk during the first 6months after diagnosis of cancer was 1.70 (95% confidence interval (95% CI) 1.66-1.75). For 26 of the 34 cancers studied, the risk of CHD was increased during the first 6months after diagnosis of cancer. The overall CHD risk decreased rapidly, but remained slightly elevated, even 10+years after diagnosis of cancer (SIR 1.07; 95% CI 1.04-1.11). The cancer sites/types for which risk of CHD was highest during the first 6months were small intestine (SIR 2.88; 95% CI 2.02-3.99), leukaemia (SIR 2.84; 95% CI 2.37-3.37), kidney (SIR 2.65; 95% CI 2.30-3.04), lung (SIR 2.56; 95% CI 2.35-2.80) and liver (SIR 2.28; 95% CI 1.91-2.71). Metastases were associated with an increased risk of CHD (SIR 1.46; 95% CI 1.28-1.65). INTERPRETATION: Most cancers were associated with an increased risk of CHD during the first 6months after diagnosis. CHD risk was related to the presence of metastates. Cancer patients may need a more aggressive treatment of classical CHD risk factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer
volume
48
pages
121 - 128
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000299866200016
  • pmid:22023886
  • scopus:83255185051
ISSN
1879-0852
DOI
10.1016/j.ejca.2011.09.015
language
English
LU publication?
yes
id
ecbce40a-4d13-498c-8c08-3ebc2c4e88bb (old id 2200186)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22023886?dopt=Abstract
date added to LUP
2011-11-02 13:35:04
date last changed
2017-08-27 05:44:30
@article{ecbce40a-4d13-498c-8c08-3ebc2c4e88bb,
  abstract     = {BACKGROUND: Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD. METHODS: All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for CHD were calculated. RESULTS: The overall CHD risk during the first 6months after diagnosis of cancer was 1.70 (95% confidence interval (95% CI) 1.66-1.75). For 26 of the 34 cancers studied, the risk of CHD was increased during the first 6months after diagnosis of cancer. The overall CHD risk decreased rapidly, but remained slightly elevated, even 10+years after diagnosis of cancer (SIR 1.07; 95% CI 1.04-1.11). The cancer sites/types for which risk of CHD was highest during the first 6months were small intestine (SIR 2.88; 95% CI 2.02-3.99), leukaemia (SIR 2.84; 95% CI 2.37-3.37), kidney (SIR 2.65; 95% CI 2.30-3.04), lung (SIR 2.56; 95% CI 2.35-2.80) and liver (SIR 2.28; 95% CI 1.91-2.71). Metastases were associated with an increased risk of CHD (SIR 1.46; 95% CI 1.28-1.65). INTERPRETATION: Most cancers were associated with an increased risk of CHD during the first 6months after diagnosis. CHD risk was related to the presence of metastates. Cancer patients may need a more aggressive treatment of classical CHD risk factors.},
  author       = {Zöller, Bengt and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1879-0852},
  language     = {eng},
  pages        = {121--128},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Risk of coronary heart disease in patients with cancer: A nationwide follow-up study from Sweden.},
  url          = {http://dx.doi.org/10.1016/j.ejca.2011.09.015},
  volume       = {48},
  year         = {2012},
}