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From PDE3B to the regulation of energy homeostasis.

Degerman, Eva LU ; Ahmad, Faiyaz; Chung, Youn Wook; Guirguis, Emilia; Omar, Bilal LU ; Stenson, Lena LU and Manganiello, Vincent (2011) In Current Opinion in Pharmacology 11. p.676-682
Abstract
The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting... (More)
The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Pharmacology
volume
11
pages
676 - 682
publisher
Elsevier
external identifiers
  • wos:000298523300018
  • pmid:22001403
  • scopus:82255192444
ISSN
1471-4973
DOI
10.1016/j.coph.2011.09.015
language
English
LU publication?
yes
id
d8a284ee-936a-45c8-938a-f73079f45a23 (old id 2200482)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22001403?dopt=Abstract
date added to LUP
2011-11-02 10:20:00
date last changed
2017-09-24 04:38:31
@article{d8a284ee-936a-45c8-938a-f73079f45a23,
  abstract     = {The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues.},
  author       = {Degerman, Eva and Ahmad, Faiyaz and Chung, Youn Wook and Guirguis, Emilia and Omar, Bilal and Stenson, Lena and Manganiello, Vincent},
  issn         = {1471-4973},
  language     = {eng},
  pages        = {676--682},
  publisher    = {Elsevier},
  series       = {Current Opinion in Pharmacology},
  title        = {From PDE3B to the regulation of energy homeostasis.},
  url          = {http://dx.doi.org/10.1016/j.coph.2011.09.015},
  volume       = {11},
  year         = {2011},
}