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Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project.

Bjørge, Tone; Lukanova, Annekatrin; Tretli, Steinar; Manjer, Jonas LU ; Ulmer, Hanno; Stocks, Tanja; Selmer, Randi; Nagel, Gabriele; Almquist, Martin LU and Concin, Hans, et al. (2011) In International Journal of Epidemiology 40. p.1667-1677
Abstract
BACKGROUND: No studies have so far evaluated the impact of the metabolic syndrome (MetS) as an entity on ovarian cancer risk. The authors aimed to examine the association between factors in the MetS, individually and combined, and risk of ovarian cancer incidence and mortality. METHODS: Altogether, 290 000 women from Austria, Norway and Sweden were enrolled during 1974-2005, with measurements taken of height, weight, blood pressure and levels of glucose, cholesterol and triglycerides. Relative risks (RRs) of ovarian cancer were estimated using Cox regression for each MetS factor in quintiles and for standardized levels (z-scores), and for a composite z-score for the MetS. RRs were corrected for random error in measurements. RESULTS: During... (More)
BACKGROUND: No studies have so far evaluated the impact of the metabolic syndrome (MetS) as an entity on ovarian cancer risk. The authors aimed to examine the association between factors in the MetS, individually and combined, and risk of ovarian cancer incidence and mortality. METHODS: Altogether, 290 000 women from Austria, Norway and Sweden were enrolled during 1974-2005, with measurements taken of height, weight, blood pressure and levels of glucose, cholesterol and triglycerides. Relative risks (RRs) of ovarian cancer were estimated using Cox regression for each MetS factor in quintiles and for standardized levels (z-scores), and for a composite z-score for the MetS. RRs were corrected for random error in measurements. RESULTS: During follow-up, 644 epithelial ovarian cancers and 388 deaths from ovarian cancer were identified. There was no overall association between MetS and ovarian cancer risk. Increasing levels of cholesterol [RR 1.52, 95% confidence interval (95% CI) 1.01-2.29, per 1-U increment of z-score] and blood pressure (RR 1.79, 95% CI 1.12-2.86) conferred, however, increased risks of mucinous and endometrioid tumours, respectively. In women below the age of 50 years, there was increased risk of ovarian cancer mortality for MetS (RR 1.52, 95% CI 1.00-2.30). Increasing levels of BMI (RR 1.17, 95% CI 1.01-1.37) conferred increased risk of ovarian cancer mortality in women above the age of 50 years. CONCLUSION: There was no overall association between MetS and ovarian cancer risk. However, increasing levels of cholesterol and blood pressure increased the risks of mucinous and endometrioid tumours, respectively. Increasing levels of BMI conferred an increased risk of ovarian cancer mortality in women above the age of 50 years. (Less)
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International Journal of Epidemiology
volume
40
pages
1667 - 1677
publisher
Oxford University Press
external identifiers
  • wos:000297868500028
  • pmid:21984693
  • scopus:84855340916
ISSN
1464-3685
DOI
10.1093/ije/dyr130
language
English
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yes
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c8b1f448-44bb-4d59-8b6b-130028395ecd (old id 2200689)
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http://www.ncbi.nlm.nih.gov/pubmed/21984693?dopt=Abstract
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2011-11-02 08:48:31
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2017-06-11 04:42:00
@article{c8b1f448-44bb-4d59-8b6b-130028395ecd,
  abstract     = {BACKGROUND: No studies have so far evaluated the impact of the metabolic syndrome (MetS) as an entity on ovarian cancer risk. The authors aimed to examine the association between factors in the MetS, individually and combined, and risk of ovarian cancer incidence and mortality. METHODS: Altogether, 290 000 women from Austria, Norway and Sweden were enrolled during 1974-2005, with measurements taken of height, weight, blood pressure and levels of glucose, cholesterol and triglycerides. Relative risks (RRs) of ovarian cancer were estimated using Cox regression for each MetS factor in quintiles and for standardized levels (z-scores), and for a composite z-score for the MetS. RRs were corrected for random error in measurements. RESULTS: During follow-up, 644 epithelial ovarian cancers and 388 deaths from ovarian cancer were identified. There was no overall association between MetS and ovarian cancer risk. Increasing levels of cholesterol [RR 1.52, 95% confidence interval (95% CI) 1.01-2.29, per 1-U increment of z-score] and blood pressure (RR 1.79, 95% CI 1.12-2.86) conferred, however, increased risks of mucinous and endometrioid tumours, respectively. In women below the age of 50 years, there was increased risk of ovarian cancer mortality for MetS (RR 1.52, 95% CI 1.00-2.30). Increasing levels of BMI (RR 1.17, 95% CI 1.01-1.37) conferred increased risk of ovarian cancer mortality in women above the age of 50 years. CONCLUSION: There was no overall association between MetS and ovarian cancer risk. However, increasing levels of cholesterol and blood pressure increased the risks of mucinous and endometrioid tumours, respectively. Increasing levels of BMI conferred an increased risk of ovarian cancer mortality in women above the age of 50 years.},
  author       = {Bjørge, Tone and Lukanova, Annekatrin and Tretli, Steinar and Manjer, Jonas and Ulmer, Hanno and Stocks, Tanja and Selmer, Randi and Nagel, Gabriele and Almquist, Martin and Concin, Hans and Hallmans, Göran and Jonsson, Håkan and Häggström, Christel and Stattin, Pär and Engeland, Anders},
  issn         = {1464-3685},
  language     = {eng},
  pages        = {1667--1677},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project.},
  url          = {http://dx.doi.org/10.1093/ije/dyr130},
  volume       = {40},
  year         = {2011},
}