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Effects of alpha-ketoglutarate on bone homeostasis and plasma amino acids in turkeys

Tatara, MR; Brodzki, A; Krupski, W; Sliwa, E; Silmanowicz, P; Majcher, P; Pierzynowski, Stefan LU and Studzinski, T (2005) In Poultry Science 84(10). p.1604-1609
Abstract
The objective of the study was to evaluate the effect of denervation and alpha-ketoglutarate (AKG) administration on the development of osteopenia in the turkey radius. At 22 d of age, all turkeys were subjected to neurectomy of the right radius. Control turkeys were given a saline solution into the crop each day for 97 d. Experimental turkeys were given 0.4 g of AKG/kg of BW into the crop each day. After 98 d, BW was not affected by the AKG treatment. Volumetric bone mineral density of the radius was measured by quantitative computed tomography. Mechanical properties were tested using a 3-point bending test. Cross-sectional area, second moment of inertia, and mean relative wall thickness were measured as well. An-Lino acid concentrations... (More)
The objective of the study was to evaluate the effect of denervation and alpha-ketoglutarate (AKG) administration on the development of osteopenia in the turkey radius. At 22 d of age, all turkeys were subjected to neurectomy of the right radius. Control turkeys were given a saline solution into the crop each day for 97 d. Experimental turkeys were given 0.4 g of AKG/kg of BW into the crop each day. After 98 d, BW was not affected by the AKG treatment. Volumetric bone mineral density of the radius was measured by quantitative computed tomography. Mechanical properties were tested using a 3-point bending test. Cross-sectional area, second moment of inertia, and mean relative wall thickness were measured as well. An-Lino acid concentrations were assessed with the use of ion-exchange chromatography. Denervation had a negative effect on all bone characteristics that were measured except bone length. The AKG had a positive effect on all bone characteristics except bone length. Plasma concentrations of proline and leucine were increased by AKG, whereas concentrations of taurine and glutamine were decreased. The turkey radius appears to be a good model for studying osteopenia because its development can be affected by treatments such as denervation and AKG administration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
long-term denervation of radius, alpha-ketoglutarate, leucine, proline, turkey
in
Poultry Science
volume
84
issue
10
pages
1604 - 1609
publisher
Poultry Science Association
external identifiers
  • pmid:16335130
  • wos:000232248600013
ISSN
1525-3171
language
English
LU publication?
yes
id
121c0704-ab27-4e4b-9a56-e89159c5c709 (old id 220645)
alternative location
http://ps.fass.org/cgi/reprint/84/10/1604
date added to LUP
2007-08-13 09:52:06
date last changed
2016-04-15 20:15:16
@article{121c0704-ab27-4e4b-9a56-e89159c5c709,
  abstract     = {The objective of the study was to evaluate the effect of denervation and alpha-ketoglutarate (AKG) administration on the development of osteopenia in the turkey radius. At 22 d of age, all turkeys were subjected to neurectomy of the right radius. Control turkeys were given a saline solution into the crop each day for 97 d. Experimental turkeys were given 0.4 g of AKG/kg of BW into the crop each day. After 98 d, BW was not affected by the AKG treatment. Volumetric bone mineral density of the radius was measured by quantitative computed tomography. Mechanical properties were tested using a 3-point bending test. Cross-sectional area, second moment of inertia, and mean relative wall thickness were measured as well. An-Lino acid concentrations were assessed with the use of ion-exchange chromatography. Denervation had a negative effect on all bone characteristics that were measured except bone length. The AKG had a positive effect on all bone characteristics except bone length. Plasma concentrations of proline and leucine were increased by AKG, whereas concentrations of taurine and glutamine were decreased. The turkey radius appears to be a good model for studying osteopenia because its development can be affected by treatments such as denervation and AKG administration.},
  author       = {Tatara, MR and Brodzki, A and Krupski, W and Sliwa, E and Silmanowicz, P and Majcher, P and Pierzynowski, Stefan and Studzinski, T},
  issn         = {1525-3171},
  keyword      = {long-term denervation of radius,alpha-ketoglutarate,leucine,proline,turkey},
  language     = {eng},
  number       = {10},
  pages        = {1604--1609},
  publisher    = {Poultry Science Association},
  series       = {Poultry Science},
  title        = {Effects of alpha-ketoglutarate on bone homeostasis and plasma amino acids in turkeys},
  volume       = {84},
  year         = {2005},
}