Advanced

Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

Nielsen, Lotte B.; Vaziri Sani, Fariba LU ; Poerksen, Sven; Andersen, Marie-Louise M.; Svensson, Jannet; Bergholdt, Regine; Pociot, Flemming; Hougaard, Philip; de Beaufort, Carine and Castano, Luis, et al. (2011) In Autoimmunity 44(8). p.616-623
Abstract
Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year after disease diagnosis in children with newly diagnosed type 1 diabetes. This cohort consists of 257 children aged < 16 years, all patients were newly diagnosed with type 1 diabetes. A Boost-test was carried out at 1, 6, and 12 months to characterize the residual beta-cell function. Carriers of the CC and CT genotype groups of... (More)
Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year after disease diagnosis in children with newly diagnosed type 1 diabetes. This cohort consists of 257 children aged < 16 years, all patients were newly diagnosed with type 1 diabetes. A Boost-test was carried out at 1, 6, and 12 months to characterize the residual beta-cell function. Carriers of the CC and CT genotype groups of the rs13266634 SNP of the SLC30A8 gene had higher stimulated C-peptide levels the first year after onset compared with those of the TT genotype group (29%, p = 0.034). CC genotype carriers were highly associated with the presence of ZnT8RAb subtype during disease progression (compared with TT, p < 0.0001). On the other hand, the TT genotype was associated with the presence of ZnT8WAb subtype during disease progression (compared with CC, p < 0.0001). The C allele of the SLC30A8 gene is associated with preserved beta-cell function in type 1 diabetes patients. The genetic determination of the rs13266634 variant on the ZnT8Ab specificity is sustained the first 12 months after the diagnosis of type 1 diabetes in a pediatric cohort. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ZnT8Ab, residual beta-cell function, type 1 diabetes, children, SLC30A8
in
Autoimmunity
volume
44
issue
8
pages
616 - 623
publisher
Taylor & Francis
external identifiers
  • wos:000296395100004
  • scopus:80155146955
ISSN
0891-6934
DOI
10.3109/08916934.2011.576724
language
English
LU publication?
yes
id
2e7ac7d4-87f7-4cd3-8d06-0b55ef4d1840 (old id 2208069)
date added to LUP
2011-12-01 08:27:19
date last changed
2017-01-01 06:35:41
@article{2e7ac7d4-87f7-4cd3-8d06-0b55ef4d1840,
  abstract     = {Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year after disease diagnosis in children with newly diagnosed type 1 diabetes. This cohort consists of 257 children aged &lt; 16 years, all patients were newly diagnosed with type 1 diabetes. A Boost-test was carried out at 1, 6, and 12 months to characterize the residual beta-cell function. Carriers of the CC and CT genotype groups of the rs13266634 SNP of the SLC30A8 gene had higher stimulated C-peptide levels the first year after onset compared with those of the TT genotype group (29%, p = 0.034). CC genotype carriers were highly associated with the presence of ZnT8RAb subtype during disease progression (compared with TT, p &lt; 0.0001). On the other hand, the TT genotype was associated with the presence of ZnT8WAb subtype during disease progression (compared with CC, p &lt; 0.0001). The C allele of the SLC30A8 gene is associated with preserved beta-cell function in type 1 diabetes patients. The genetic determination of the rs13266634 variant on the ZnT8Ab specificity is sustained the first 12 months after the diagnosis of type 1 diabetes in a pediatric cohort.},
  author       = {Nielsen, Lotte B. and Vaziri Sani, Fariba and Poerksen, Sven and Andersen, Marie-Louise M. and Svensson, Jannet and Bergholdt, Regine and Pociot, Flemming and Hougaard, Philip and de Beaufort, Carine and Castano, Luis and Mortensen, Henrik B. and Lernmark, Åke and Hansen, Lars},
  issn         = {0891-6934},
  keyword      = {ZnT8Ab,residual beta-cell function,type 1 diabetes,children,SLC30A8},
  language     = {eng},
  number       = {8},
  pages        = {616--623},
  publisher    = {Taylor & Francis},
  series       = {Autoimmunity},
  title        = {Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes},
  url          = {http://dx.doi.org/10.3109/08916934.2011.576724},
  volume       = {44},
  year         = {2011},
}