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Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects

Norberg, J.; Graff, C.; Almkvist, O.; Ewers, M.; Frisoni, G. B.; Froelich, L.; Hampel, H.; Jones, R. W.; Kehoe, P. G. and Lenoir, H., et al. (2011) In Dementia and Geriatric Cognitive Disorders 32(2). p.135-142
Abstract
Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the... (More)
Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent. Copyright (C) 2011 S. Karger AG, Basel (Less)
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publication status
published
subject
keywords
Alzheimer's disease, APOE epsilon 4 allele, Europe, Gradient
in
Dementia and Geriatric Cognitive Disorders
volume
32
issue
2
pages
135 - 142
publisher
Karger
external identifiers
  • wos:000295875400008
  • scopus:80054863058
ISSN
1420-8008
DOI
10.1159/000330492
language
English
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yes
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6e2fd674-6f23-44f8-96ae-41b69d2aa4aa (old id 2212042)
date added to LUP
2011-12-01 08:36:20
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2017-08-13 03:24:35
@article{6e2fd674-6f23-44f8-96ae-41b69d2aa4aa,
  abstract     = {Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent. Copyright (C) 2011 S. Karger AG, Basel},
  author       = {Norberg, J. and Graff, C. and Almkvist, O. and Ewers, M. and Frisoni, G. B. and Froelich, L. and Hampel, H. and Jones, R. W. and Kehoe, P. G. and Lenoir, H. and Minthon, Lennart and Nobili, F. and Rikkert, M. Olde and Rigaud, A. -S. and Scheltens, P. and Soininen, H. and Spiru, L. and Tsolaki, M. and Wahlund, L. -O. and Vellas, B. and Wilcock, G. and Elias-Sonnenschein, L. S. and Verhey, F. R. J. and Visser, P. J.},
  issn         = {1420-8008},
  keyword      = {Alzheimer's disease,APOE epsilon 4 allele,Europe,Gradient},
  language     = {eng},
  number       = {2},
  pages        = {135--142},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects},
  url          = {http://dx.doi.org/10.1159/000330492},
  volume       = {32},
  year         = {2011},
}