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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C. and Hwang, Shih-Jen, et al. (2011) In Nature 478(7367). p.103-109
Abstract
Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to... (More)
Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. (Less)
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478
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7367
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103 - 109
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Nature Publishing Group
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  • scopus:80053907554
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0028-0836
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10.1038/nature10405
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English
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515d28dd-2205-4576-9fc5-1637e45f83b9 (old id 2212305)
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2011-12-01 08:33:24
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@article{515d28dd-2205-4576-9fc5-1637e45f83b9,
  abstract     = {Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.},
  author       = {Ehret, Georg B. and Munroe, Patricia B. and Rice, Kenneth M. and Bochud, Murielle and Johnson, Andrew D. and Chasman, Daniel I. and Smith, Albert V. and Tobin, Martin D. and Verwoert, Germaine C. and Hwang, Shih-Jen and Pihur, Vasyl and Vollenweider, Peter and O'Reilly, Paul F. and Amin, Najaf and Bragg-Gresham, Jennifer L. and Teumer, Alexander and Glazer, Nicole L. and Launer, Lenore and Zhao, Jing Hua and Aulchenko, Yurii and Heath, Simon and Sober, Siim and Parsa, Afshin and Luan, Jian'an and Arora, Pankaj and Dehghan, Abbas and Zhang, Feng and Lucas, Gavin and Hicks, Andrew A. and Jackson, Anne U. and Peden, John F. and Tanaka, Toshiko and Wild, Sarah H. and Rudan, Igor and Igl, Wilmar and Milaneschi, Yuri and Parker, Alex N. and Fava, Cristiano and Chambers, John C. and Fox, Ervin R. and Kumari, Meena and Go, Min Jin and van der Harst, Pim and Kao, Wen Hong Linda and Sjögren, Marketa and Vinay, D. G. and Alexander, Myriam and Tabara, Yasuharu and Shaw-Hawkins, Sue and Whincup, Peter H. and Liu, Yongmei and Shi, Gang and Kuusisto, Johanna and Tayo, Bamidele and Seielstad, Mark and Sim, Xueling and Khanh-Dung Hoang, Nguyen and Lehtimaki, Terho and Matullo, Giuseppe and Wu, Ying and Gaunt, Tom R. and Onland-Moret, N. Charlotte and Cooper, Matthew N. and Platou, Carl G. P. and Org, Elin and Hardy, Rebecca and Dahgam, Santosh and Palmen, Jutta and Vitart, Veronique and Braund, Peter S. and Kuznetsova, Tatiana and Uiterwaal, Cuno S. P. 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M. and Hartikainen, Anna-Liisa and Beckmann, Jacques S. and Boerwinkle, Eric and Vasan, Ramachandran S. and Boehnke, Michael and Larson, Martin G. and Jarvelin, Marjo-Riitta and Psaty, Bruce M. and Abecasis, Goncalo R. and Chakravarti, Aravinda and Elliott, Paul and van Duijn, Cornelia M. and Newton-Cheh, Christopher and Levy, Daniel and Caulfield, Mark J. and Johnson, Toby},
  issn         = {0028-0836},
  language     = {eng},
  number       = {7367},
  pages        = {103--109},
  publisher    = {Nature Publishing Group},
  series       = {Nature},
  title        = {Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk},
  url          = {http://dx.doi.org/10.1038/nature10405},
  volume       = {478},
  year         = {2011},
}