Advanced

Increased incidence of childhood, prostate and breast cancers in relatives of childhood cancer patients.

Magnusson, Susanne LU ; Wiebe, Thomas LU ; Kristoffersson, Ulf LU ; Jernström, Helena LU and Olsson, Håkan LU (2012) In Familial Cancer 11. p.145-155
Abstract
Whether cancer predisposing familial factors are associated with childhood tumors is unclear. The purpose was to study the incidence of childhood and adult tumors in extended families of children with cancer. Family history of cancer was obtained through questionnaires, and the Swedish Population-, and Cancer Registries for 194 childhood cancer patients aged ≤18 years, diagnosed 1972-2009. Standardized cancer incidence ratios (SIR), and 95% confidence intervals (CI) were estimated and compared with expected rates. Overall, 21 of the 194 patients had any relative with a childhood tumor. When restricted to first- to third degree relatives, increased incidences of childhood (SIR: 2.5; 95% CI: 1.3-4.4) and adult tumors (SIR: 1.5; 95% CI:... (More)
Whether cancer predisposing familial factors are associated with childhood tumors is unclear. The purpose was to study the incidence of childhood and adult tumors in extended families of children with cancer. Family history of cancer was obtained through questionnaires, and the Swedish Population-, and Cancer Registries for 194 childhood cancer patients aged ≤18 years, diagnosed 1972-2009. Standardized cancer incidence ratios (SIR), and 95% confidence intervals (CI) were estimated and compared with expected rates. Overall, 21 of the 194 patients had any relative with a childhood tumor. When restricted to first- to third degree relatives, increased incidences of childhood (SIR: 2.5; 95% CI: 1.3-4.4) and adult tumors (SIR: 1.5; 95% CI: 1.3-1.7), especially in the prostate (SIR: 2.7; 95% CI: 1.9-3.8) and breast (SIR: 1.7; 95% CI: 1.2-2.4) were observed. Prostate and breast cancers were observed at earlier than average ages. No TP53 mutations or known cancer predisposing syndromes were found in families with multiple childhood tumors. Familial factors may increase the risk for childhood cancer and modify the age of onset of common adult tumors. Studying extended families with multiple childhood tumors may be a valuable approach to understanding the etiology of childhood tumors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Familial Cancer
volume
11
pages
145 - 155
publisher
Kluwer
external identifiers
  • wos:000301508300019
  • pmid:22120843
  • scopus:84858295562
ISSN
1389-9600
DOI
10.1007/s10689-011-9493-3
language
English
LU publication?
yes
id
cbdf3be3-afa9-4c92-bce3-7d9ca2488adf (old id 2220268)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22120843?dopt=Abstract
date added to LUP
2011-12-03 10:30:22
date last changed
2017-01-01 03:52:30
@article{cbdf3be3-afa9-4c92-bce3-7d9ca2488adf,
  abstract     = {Whether cancer predisposing familial factors are associated with childhood tumors is unclear. The purpose was to study the incidence of childhood and adult tumors in extended families of children with cancer. Family history of cancer was obtained through questionnaires, and the Swedish Population-, and Cancer Registries for 194 childhood cancer patients aged ≤18 years, diagnosed 1972-2009. Standardized cancer incidence ratios (SIR), and 95% confidence intervals (CI) were estimated and compared with expected rates. Overall, 21 of the 194 patients had any relative with a childhood tumor. When restricted to first- to third degree relatives, increased incidences of childhood (SIR: 2.5; 95% CI: 1.3-4.4) and adult tumors (SIR: 1.5; 95% CI: 1.3-1.7), especially in the prostate (SIR: 2.7; 95% CI: 1.9-3.8) and breast (SIR: 1.7; 95% CI: 1.2-2.4) were observed. Prostate and breast cancers were observed at earlier than average ages. No TP53 mutations or known cancer predisposing syndromes were found in families with multiple childhood tumors. Familial factors may increase the risk for childhood cancer and modify the age of onset of common adult tumors. Studying extended families with multiple childhood tumors may be a valuable approach to understanding the etiology of childhood tumors.},
  author       = {Magnusson, Susanne and Wiebe, Thomas and Kristoffersson, Ulf and Jernström, Helena and Olsson, Håkan},
  issn         = {1389-9600},
  language     = {eng},
  pages        = {145--155},
  publisher    = {Kluwer},
  series       = {Familial Cancer},
  title        = {Increased incidence of childhood, prostate and breast cancers in relatives of childhood cancer patients.},
  url          = {http://dx.doi.org/10.1007/s10689-011-9493-3},
  volume       = {11},
  year         = {2012},
}