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Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age.

Platonov, Pyotr LU ; Mitrofanova, Lubov B; Orshanskaya, Victoria and Ho, Siew Yen (2011) In Journal of the American College of Cardiology 58(21). p.2225-2232
Abstract
OBJECTIVES:

The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF).



BACKGROUND:

Development of fibrosis in atrial walls is associated with deterioration of atrial conduction and predisposes to AF in experiment. Human data, however, are scarce, and whether fibrosis is a cause or consequence of AF is not known.



METHODS:

Medical records for consecutive autopsies were checked for AF history and duration. Atrial specimens from 30 patients (ages 64 ± 12 years) were collected in 3 equal age-matched groups as patients without AF history, with paroxysmal AF, or with permanent AF. Tissue samples... (More)
OBJECTIVES:

The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF).



BACKGROUND:

Development of fibrosis in atrial walls is associated with deterioration of atrial conduction and predisposes to AF in experiment. Human data, however, are scarce, and whether fibrosis is a cause or consequence of AF is not known.



METHODS:

Medical records for consecutive autopsies were checked for AF history and duration. Atrial specimens from 30 patients (ages 64 ± 12 years) were collected in 3 equal age-matched groups as patients without AF history, with paroxysmal AF, or with permanent AF. Tissue samples were obtained at the level of superior pulmonary veins, inferior pulmonary veins, center of posterior left atrial wall, terminal crest, and Bachmann's bundle. Histology sections were assessed for extent of fibrosis, fatty tissues, and inflammatory infiltration at each location.



RESULTS:

No correlation was observed between age and fibrosis at any location. Fibrosis extent and fatty infiltration were twofold to threefold higher at all locations in patients with history of AF and correlated with lymphomononuclear infiltration. Patients with permanent AF had greater fibrosis extent than did patients with paroxysmal AF.



CONCLUSIONS:

In post-mortem material, structural changes in the atria were not associated with age, but were significantly correlated with presence of AF and its severity. Our findings suggest that age-related changes per se are unlikely to be the sole cause of advanced fibrosis underlying AF. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American College of Cardiology
volume
58
issue
21
pages
2225 - 2232
publisher
Elsevier USA
external identifiers
  • wos:000296761600011
  • pmid:22078429
  • scopus:80855144817
ISSN
0735-1097
DOI
10.1016/j.jacc.2011.05.061
language
English
LU publication?
yes
id
c1fd2347-7f9a-4f5e-abff-2f3471db54e2 (old id 2220868)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22078429?dopt=Abstract
date added to LUP
2011-12-02 20:42:45
date last changed
2017-10-22 03:06:39
@article{c1fd2347-7f9a-4f5e-abff-2f3471db54e2,
  abstract     = {OBJECTIVES:<br/><br>
The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF).<br/><br>
<br/><br>
BACKGROUND:<br/><br>
Development of fibrosis in atrial walls is associated with deterioration of atrial conduction and predisposes to AF in experiment. Human data, however, are scarce, and whether fibrosis is a cause or consequence of AF is not known.<br/><br>
<br/><br>
METHODS:<br/><br>
Medical records for consecutive autopsies were checked for AF history and duration. Atrial specimens from 30 patients (ages 64 ± 12 years) were collected in 3 equal age-matched groups as patients without AF history, with paroxysmal AF, or with permanent AF. Tissue samples were obtained at the level of superior pulmonary veins, inferior pulmonary veins, center of posterior left atrial wall, terminal crest, and Bachmann's bundle. Histology sections were assessed for extent of fibrosis, fatty tissues, and inflammatory infiltration at each location.<br/><br>
<br/><br>
RESULTS:<br/><br>
No correlation was observed between age and fibrosis at any location. Fibrosis extent and fatty infiltration were twofold to threefold higher at all locations in patients with history of AF and correlated with lymphomononuclear infiltration. Patients with permanent AF had greater fibrosis extent than did patients with paroxysmal AF.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
In post-mortem material, structural changes in the atria were not associated with age, but were significantly correlated with presence of AF and its severity. Our findings suggest that age-related changes per se are unlikely to be the sole cause of advanced fibrosis underlying AF.},
  author       = {Platonov, Pyotr and Mitrofanova, Lubov B and Orshanskaya, Victoria and Ho, Siew Yen},
  issn         = {0735-1097},
  language     = {eng},
  number       = {21},
  pages        = {2225--2232},
  publisher    = {Elsevier USA},
  series       = {Journal of the American College of Cardiology},
  title        = {Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age.},
  url          = {http://dx.doi.org/10.1016/j.jacc.2011.05.061},
  volume       = {58},
  year         = {2011},
}