Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.
(2011) In Documenta Ophthalmologica 123. p.193-198- Abstract
- The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas... (More)
- The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2221096
- author
- Tyrberg, Maria LU ; Lindblad, Ulf LU ; Melander, Arne LU ; Lövestam Adrian, Monica LU ; Ponjavic, Vesna LU and Andréasson, Sten LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Documenta Ophthalmologica
- volume
- 123
- pages
- 193 - 198
- publisher
- Springer
- external identifiers
-
- wos:000297848800007
- pmid:22057379
- scopus:84857047811
- pmid:22057379
- ISSN
- 1573-2622
- DOI
- 10.1007/s10633-011-9298-6
- language
- English
- LU publication?
- yes
- id
- 739d14d2-a709-42a4-b868-4cd7412944ec (old id 2221096)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22057379?dopt=Abstract
- date added to LUP
- 2016-04-04 07:40:23
- date last changed
- 2022-03-15 07:14:21
@article{739d14d2-a709-42a4-b868-4cd7412944ec, abstract = {{The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.}}, author = {{Tyrberg, Maria and Lindblad, Ulf and Melander, Arne and Lövestam Adrian, Monica and Ponjavic, Vesna and Andréasson, Sten}}, issn = {{1573-2622}}, language = {{eng}}, pages = {{193--198}}, publisher = {{Springer}}, series = {{Documenta Ophthalmologica}}, title = {{Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.}}, url = {{http://dx.doi.org/10.1007/s10633-011-9298-6}}, doi = {{10.1007/s10633-011-9298-6}}, volume = {{123}}, year = {{2011}}, }