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Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.

Tyrberg, Maria LU ; Lindblad, Ulf LU ; Melander, Arne LU ; Lövestam Adrian, Monica LU ; Ponjavic, Vesna LU and Andréasson, Sten LU (2011) In Documenta Ophthalmologica 123. p.193-198
Abstract
The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas... (More)
The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Documenta Ophthalmologica
volume
123
pages
193 - 198
publisher
Springer
external identifiers
  • wos:000297848800007
  • pmid:22057379
  • scopus:84857047811
ISSN
1573-2622
DOI
10.1007/s10633-011-9298-6
language
English
LU publication?
yes
id
739d14d2-a709-42a4-b868-4cd7412944ec (old id 2221096)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22057379?dopt=Abstract
date added to LUP
2011-12-02 19:28:26
date last changed
2017-09-24 04:37:01
@article{739d14d2-a709-42a4-b868-4cd7412944ec,
  abstract     = {The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.},
  author       = {Tyrberg, Maria and Lindblad, Ulf and Melander, Arne and Lövestam Adrian, Monica and Ponjavic, Vesna and Andréasson, Sten},
  issn         = {1573-2622},
  language     = {eng},
  pages        = {193--198},
  publisher    = {Springer},
  series       = {Documenta Ophthalmologica},
  title        = {Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.},
  url          = {http://dx.doi.org/10.1007/s10633-011-9298-6},
  volume       = {123},
  year         = {2011},
}