Automatic Segmentation of the Fetus in 3D Magnetic Resonance Images Using Deep Learning : Accurate and Fast Fetal Volume Quantification for Clinical Use
Ryd, Daniel LU ; Nilsson, Amanda LU ; Heiberg, Einar LU and Hedström, Erik LU
(2023)
In Pediatric Cardiology
44(6).
p.1311-1318
- Abstract
Magnetic resonance imaging (MRI) provides images for estimating fetal volume and weight, but manual delineations are time consuming. The aims were to (1) validate an algorithm to automatically quantify fetal volume by MRI; (2) compare fetal weight by Hadlock's formulas to that of MRI; and (3) quantify fetal blood flow and index flow to fetal weight by MRI. Forty-two fetuses at 36 (29-39) weeks gestation underwent MRI. A neural network was trained to segment the fetus, with 20 datasets for training and validation, and 22 for testing. Hadlock's formulas 1-4 with biometric parameters from MRI were compared with weight by MRI. Blood flow was measured using phase-contrast MRI and indexed to fetal weight. Bland-Altman analysis assessed the... (More)
Magnetic resonance imaging (MRI) provides images for estimating fetal volume and weight, but manual delineations are time consuming. The aims were to (1) validate an algorithm to automatically quantify fetal volume by MRI; (2) compare fetal weight by Hadlock's formulas to that of MRI; and (3) quantify fetal blood flow and index flow to fetal weight by MRI. Forty-two fetuses at 36 (29-39) weeks gestation underwent MRI. A neural network was trained to segment the fetus, with 20 datasets for training and validation, and 22 for testing. Hadlock's formulas 1-4 with biometric parameters from MRI were compared with weight by MRI. Blood flow was measured using phase-contrast MRI and indexed to fetal weight. Bland-Altman analysis assessed the agreement between automatic and manual fetal segmentation and the agreement between Hadlock's formulas and fetal segmentation for fetal weight. Bias and 95% limits of agreement were for automatic versus manual measurements 4.5 ± 351 ml (0.01% ± 11%), and for Hadlock 1-4 vs MRI 108 ± 435 g (3% ± 14%), 211 ± 468 g (7% ± 15%), 106 ± 425 g (4% ± 14%), and 179 ± 472 g (6% ± 15%), respectively. Umbilical venous flow was 406 (range 151-650) ml/min (indexed 162 (range 52-220) ml/min/kg), and descending aortic flow was 763 (range 481-1160) ml/min (indexed 276 (range 189-386) ml/min/kg). The automatic method showed good agreement with manual measurements and saves considerable analysis time. Hadlock 1-4 generally agree with MRI. This study also illustrates the confounding effects of fetal weight on absolute blood flow, and emphasizes the benefit of indexed measurements for physiological assessment.
(Less)
- author
- Ryd, Daniel
LU
; Nilsson, Amanda
LU
; Heiberg, Einar
LU
and Hedström, Erik
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Cardiology
- volume
- 44
- issue
- 6
- pages
- 1311 - 1318
- publisher
- Springer
- external identifiers
-
- scopus:85141373941
- pmid:36334112
- ISSN
- 0172-0643
- DOI
- 10.1007/s00246-022-03038-0
- language
- English
- LU publication?
- yes
- additional info
- © 2022. The Author(s).
- id
- 22256edd-5fce-4941-9cc1-04e435df28e9
- date added to LUP
- 2022-11-07 07:57:36
- date last changed
- 2024-04-18 15:21:48
@article{22256edd-5fce-4941-9cc1-04e435df28e9,
abstract = {{<p>Magnetic resonance imaging (MRI) provides images for estimating fetal volume and weight, but manual delineations are time consuming. The aims were to (1) validate an algorithm to automatically quantify fetal volume by MRI; (2) compare fetal weight by Hadlock's formulas to that of MRI; and (3) quantify fetal blood flow and index flow to fetal weight by MRI. Forty-two fetuses at 36 (29-39) weeks gestation underwent MRI. A neural network was trained to segment the fetus, with 20 datasets for training and validation, and 22 for testing. Hadlock's formulas 1-4 with biometric parameters from MRI were compared with weight by MRI. Blood flow was measured using phase-contrast MRI and indexed to fetal weight. Bland-Altman analysis assessed the agreement between automatic and manual fetal segmentation and the agreement between Hadlock's formulas and fetal segmentation for fetal weight. Bias and 95% limits of agreement were for automatic versus manual measurements 4.5 ± 351 ml (0.01% ± 11%), and for Hadlock 1-4 vs MRI 108 ± 435 g (3% ± 14%), 211 ± 468 g (7% ± 15%), 106 ± 425 g (4% ± 14%), and 179 ± 472 g (6% ± 15%), respectively. Umbilical venous flow was 406 (range 151-650) ml/min (indexed 162 (range 52-220) ml/min/kg), and descending aortic flow was 763 (range 481-1160) ml/min (indexed 276 (range 189-386) ml/min/kg). The automatic method showed good agreement with manual measurements and saves considerable analysis time. Hadlock 1-4 generally agree with MRI. This study also illustrates the confounding effects of fetal weight on absolute blood flow, and emphasizes the benefit of indexed measurements for physiological assessment.</p>}},
author = {{Ryd, Daniel and Nilsson, Amanda and Heiberg, Einar and Hedström, Erik}},
issn = {{0172-0643}},
language = {{eng}},
number = {{6}},
pages = {{1311--1318}},
publisher = {{Springer}},
series = {{Pediatric Cardiology}},
title = {{Automatic Segmentation of the Fetus in 3D Magnetic Resonance Images Using Deep Learning : Accurate and Fast Fetal Volume Quantification for Clinical Use}},
url = {{http://dx.doi.org/10.1007/s00246-022-03038-0}},
doi = {{10.1007/s00246-022-03038-0}},
volume = {{44}},
year = {{2023}},
}