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Joint Nordic prospective study on human herpesvirus 8 and multiple myeloma risk

Tedeschi, R; Luostarinen, T; De Paoli, P; Gislefoss, RE; Tenkanen, L; Virtamo, J; Koskela, P; Hallmans, G; Lehtinen, M and Dillner, Joakim LU (2005) In British Journal of Cancer 93(7). p.834-837
Abstract
An association between human herpesvirus 8 (HHV8) and multiple myeloma ( MM) has been reported, though most studies have not confirmed such association. To follow-up on a previous prospective seroepidemiological study, where HHV8 tended to associate with MM risk, we linked five large serum banks in the Nordic countries with the Nordic cancer registries and 329 prospectively occurring cases of MM were identified, together with 1631 control subjects matched by age and gender. The HHV8 seroprevalences among cases and controls were similar ( 12 and 15%, respectively) and HHV8 seropositivity did not associate with the risk of MM, neither when considering positivity for lytic antibodies ( relative risk (RR) 0.8, 95% confidence interval (CI) 0.5... (More)
An association between human herpesvirus 8 (HHV8) and multiple myeloma ( MM) has been reported, though most studies have not confirmed such association. To follow-up on a previous prospective seroepidemiological study, where HHV8 tended to associate with MM risk, we linked five large serum banks in the Nordic countries with the Nordic cancer registries and 329 prospectively occurring cases of MM were identified, together with 1631 control subjects matched by age and gender. The HHV8 seroprevalences among cases and controls were similar ( 12 and 15%, respectively) and HHV8 seropositivity did not associate with the risk of MM, neither when considering positivity for lytic antibodies ( relative risk (RR) 0.8, 95% confidence interval (CI) 0.5 - 1.1) nor for latent antibodies ( RR 0.6, 95% CI 0.1 - 2.7). Similar risks were seen when analysis was restricted to case - control sets with at least 2 years lag before diagnosis ( RR 0.8, 95% CI 0.5 - 1.2 and RR 0.9, 95% CI 0.1 - 4.2). In conclusion, the data indicate that HHV8 infection is not associated with MM. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nested, HHV8, multiple myeloma, immunofluorescence, biobank, case-control study
in
British Journal of Cancer
volume
93
issue
7
pages
834 - 837
publisher
Nature Publishing Group
external identifiers
  • wos:000232146100017
  • pmid:16136049
  • scopus:27144432832
ISSN
1532-1827
DOI
10.1038/sj.bjc.6602751
language
English
LU publication?
yes
id
7ff95c2b-fd15-42e5-99b9-2417156d4e82 (old id 223475)
date added to LUP
2007-08-16 09:23:00
date last changed
2017-01-01 05:16:32
@article{7ff95c2b-fd15-42e5-99b9-2417156d4e82,
  abstract     = {An association between human herpesvirus 8 (HHV8) and multiple myeloma ( MM) has been reported, though most studies have not confirmed such association. To follow-up on a previous prospective seroepidemiological study, where HHV8 tended to associate with MM risk, we linked five large serum banks in the Nordic countries with the Nordic cancer registries and 329 prospectively occurring cases of MM were identified, together with 1631 control subjects matched by age and gender. The HHV8 seroprevalences among cases and controls were similar ( 12 and 15%, respectively) and HHV8 seropositivity did not associate with the risk of MM, neither when considering positivity for lytic antibodies ( relative risk (RR) 0.8, 95% confidence interval (CI) 0.5 - 1.1) nor for latent antibodies ( RR 0.6, 95% CI 0.1 - 2.7). Similar risks were seen when analysis was restricted to case - control sets with at least 2 years lag before diagnosis ( RR 0.8, 95% CI 0.5 - 1.2 and RR 0.9, 95% CI 0.1 - 4.2). In conclusion, the data indicate that HHV8 infection is not associated with MM.},
  author       = {Tedeschi, R and Luostarinen, T and De Paoli, P and Gislefoss, RE and Tenkanen, L and Virtamo, J and Koskela, P and Hallmans, G and Lehtinen, M and Dillner, Joakim},
  issn         = {1532-1827},
  keyword      = {nested,HHV8,multiple myeloma,immunofluorescence,biobank,case-control study},
  language     = {eng},
  number       = {7},
  pages        = {834--837},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Joint Nordic prospective study on human herpesvirus 8 and multiple myeloma risk},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6602751},
  volume       = {93},
  year         = {2005},
}