Colposcopic and histopathologic evaluation of women participating in population-based screening for human papillomavirus deoxyribonucleic acid persistence
(2005) In American Journal of Obstetrics and Gynecology 193(3). p.650-657- Abstract
- Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I... (More)
- Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I I controls were referred to colposcopy, and 84.8% attended. Results: Histopathology from colposcopically directed biopsies confirmed cervical intraepithelial neoplasia grade 2 or 3 in 28 of 160 of the women with human papillornavirus deoxyribonucleic acid persistence and in 2 of 95 among controls. Conclusion: Among women with normal Papanicolaou smear attending population-based screening, the positive predictive value of human papillomavirus deoxyribonucleic acid persistence for detection of biopsy-confirmed cervical intraepithelial neoplasia 2 or 3 was 29%. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/223810
- author
- Elfgren, K ; Rylander, E ; Radberg, T ; Strander, B ; Strand, A ; Paajanen, K ; Sjoberg, I ; Ryd, W ; Silins, I and Dillner, Joakim LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- colposcopy, human papillamavirus, deoxyribonucleic acid, cervical, cancer screening
- in
- American Journal of Obstetrics and Gynecology
- volume
- 193
- issue
- 3
- pages
- 650 - 657
- publisher
- Elsevier
- external identifiers
-
- wos:000232013300008
- pmid:16150255
- scopus:24344483174
- pmid:16150255
- ISSN
- 1097-6868
- DOI
- 10.1016/j.ajog.2005.01.056
- language
- English
- LU publication?
- yes
- id
- 999d6cdb-d632-48a9-ac9b-620b5b437c41 (old id 223810)
- date added to LUP
- 2016-04-01 12:30:13
- date last changed
- 2022-03-29 01:46:26
@article{999d6cdb-d632-48a9-ac9b-620b5b437c41,
abstract = {{Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I I controls were referred to colposcopy, and 84.8% attended. Results: Histopathology from colposcopically directed biopsies confirmed cervical intraepithelial neoplasia grade 2 or 3 in 28 of 160 of the women with human papillornavirus deoxyribonucleic acid persistence and in 2 of 95 among controls. Conclusion: Among women with normal Papanicolaou smear attending population-based screening, the positive predictive value of human papillomavirus deoxyribonucleic acid persistence for detection of biopsy-confirmed cervical intraepithelial neoplasia 2 or 3 was 29%.}},
author = {{Elfgren, K and Rylander, E and Radberg, T and Strander, B and Strand, A and Paajanen, K and Sjoberg, I and Ryd, W and Silins, I and Dillner, Joakim}},
issn = {{1097-6868}},
keywords = {{colposcopy; human papillamavirus; deoxyribonucleic acid; cervical; cancer screening}},
language = {{eng}},
number = {{3}},
pages = {{650--657}},
publisher = {{Elsevier}},
series = {{American Journal of Obstetrics and Gynecology}},
title = {{Colposcopic and histopathologic evaluation of women participating in population-based screening for human papillomavirus deoxyribonucleic acid persistence}},
url = {{http://dx.doi.org/10.1016/j.ajog.2005.01.056}},
doi = {{10.1016/j.ajog.2005.01.056}},
volume = {{193}},
year = {{2005}},
}