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Colposcopic and histopathologic evaluation of women participating in population-based screening for human papillomavirus deoxyribonucleic acid persistence

Elfgren, K; Rylander, E; Radberg, T; Strander, B; Strand, A; Paajanen, K; Sjoberg, I; Ryd, W; Silins, I and Dillner, Joakim LU (2005) In American Journal of Obstetrics and Gynecology 193(3). p.650-657
Abstract
Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I... (More)
Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I I controls were referred to colposcopy, and 84.8% attended. Results: Histopathology from colposcopically directed biopsies confirmed cervical intraepithelial neoplasia grade 2 or 3 in 28 of 160 of the women with human papillornavirus deoxyribonucleic acid persistence and in 2 of 95 among controls. Conclusion: Among women with normal Papanicolaou smear attending population-based screening, the positive predictive value of human papillomavirus deoxyribonucleic acid persistence for detection of biopsy-confirmed cervical intraepithelial neoplasia 2 or 3 was 29%. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colposcopy, human papillamavirus, deoxyribonucleic acid, cervical, cancer screening
in
American Journal of Obstetrics and Gynecology
volume
193
issue
3
pages
650 - 657
publisher
Elsevier
external identifiers
  • wos:000232013300008
  • pmid:16150255
  • scopus:24344483174
ISSN
1097-6868
DOI
10.1016/j.ajog.2005.01.056
language
English
LU publication?
yes
id
999d6cdb-d632-48a9-ac9b-620b5b437c41 (old id 223810)
date added to LUP
2007-08-07 12:43:41
date last changed
2017-08-13 03:46:22
@article{999d6cdb-d632-48a9-ac9b-620b5b437c41,
  abstract     = {Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillornavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n = 341) and an equal number from the control group were human papillornavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and I I I controls were referred to colposcopy, and 84.8% attended. Results: Histopathology from colposcopically directed biopsies confirmed cervical intraepithelial neoplasia grade 2 or 3 in 28 of 160 of the women with human papillornavirus deoxyribonucleic acid persistence and in 2 of 95 among controls. Conclusion: Among women with normal Papanicolaou smear attending population-based screening, the positive predictive value of human papillomavirus deoxyribonucleic acid persistence for detection of biopsy-confirmed cervical intraepithelial neoplasia 2 or 3 was 29%.},
  author       = {Elfgren, K and Rylander, E and Radberg, T and Strander, B and Strand, A and Paajanen, K and Sjoberg, I and Ryd, W and Silins, I and Dillner, Joakim},
  issn         = {1097-6868},
  keyword      = {colposcopy,human papillamavirus,deoxyribonucleic acid,cervical,cancer screening},
  language     = {eng},
  number       = {3},
  pages        = {650--657},
  publisher    = {Elsevier},
  series       = {American Journal of Obstetrics and Gynecology},
  title        = {Colposcopic and histopathologic evaluation of women participating in population-based screening for human papillomavirus deoxyribonucleic acid persistence},
  url          = {http://dx.doi.org/10.1016/j.ajog.2005.01.056},
  volume       = {193},
  year         = {2005},
}