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Urinary bisphenol a, f and s levels and semen quality in young adult danish men

Benson, Thea Emily ; Gaml-Sørensen, Anne ; Ernst, Andreas ; Brix, Nis ; Hougaard, Karin Sørig ; Hærvig, Katia Keglberg ; Bonde, Jens Peter Ellekilde ; Tøttenborg, Sandra Søgaard ; Lindh, Christian H. LU and Ramlau-Hansen, Cecilia Høst , et al. (2021) In International Journal of Environmental Research and Public Health 18(4).
Abstract

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are struc-turally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross– sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concen-tration, total sperm count, sperm motility, and sperm morphology. Associations... (More)

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are struc-turally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross– sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concen-tration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bisphenol, Endocrine disruptor, Epidemiology, Male fertility, Semen quality
in
International Journal of Environmental Research and Public Health
volume
18
issue
4
article number
1742
pages
12 pages
publisher
MDPI AG
external identifiers
  • scopus:85100696649
ISSN
1661-7827
DOI
10.3390/ijerph18041742
language
English
LU publication?
yes
id
223b01b7-91e5-4f34-b772-b14268cd854b
date added to LUP
2021-02-23 09:23:49
date last changed
2021-02-23 09:23:49
@article{223b01b7-91e5-4f34-b772-b14268cd854b,
  abstract     = {<p>Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are struc-turally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross– sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concen-tration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.</p>},
  author       = {Benson, Thea Emily and Gaml-Sørensen, Anne and Ernst, Andreas and Brix, Nis and Hougaard, Karin Sørig and Hærvig, Katia Keglberg and Bonde, Jens Peter Ellekilde and Tøttenborg, Sandra Søgaard and Lindh, Christian H. and Ramlau-Hansen, Cecilia Høst and Toft, Gunnar},
  issn         = {1661-7827},
  language     = {eng},
  number       = {4},
  publisher    = {MDPI AG},
  series       = {International Journal of Environmental Research and Public Health},
  title        = {Urinary bisphenol a, f and s levels and semen quality in young adult danish men},
  url          = {http://dx.doi.org/10.3390/ijerph18041742},
  doi          = {10.3390/ijerph18041742},
  volume       = {18},
  year         = {2021},
}