4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study
(2005) In Cancer Epidemiology Biomarkers & Prevention 14(9). p.2118-2124- Abstract
- The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladder, pharynx, larynx, oral cavity, leukemias, and chronic obstructive pulmonary disease or emphysema deaths). All individuals were never smokers or ex smokers for > 10 years. 4-ABP-Hb adducts were analyzed in peripheral blood collected before the onset of the disease (median, 7 years). Overall, 4-ABP-Hb adducts were higher, although not... (More)
- The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladder, pharynx, larynx, oral cavity, leukemias, and chronic obstructive pulmonary disease or emphysema deaths). All individuals were never smokers or ex smokers for > 10 years. 4-ABP-Hb adducts were analyzed in peripheral blood collected before the onset of the disease (median, 7 years). Overall, 4-ABP-Hb adducts were higher, although not statistically significantly so, in cases (as a whole) than controls. In the control population, high fruit and vegetable consumption significantly lowered the frequency of detectable adducts (Fisher's exact test, P = 0.025). Restricting the analysis to women, 4-ABP-Hb adducts were higher in cases than controls (Mann-Whitney P = 0.036) and the odds ratio (OR) for the presence/absence of adducts was 2.42 [95% confidence interval (95% CI), 1.18-4.981. Moreover, the association of adducts with the individual cancer types was stronger in women than in the whole study population, although statistically significant only for leukemias (OR, 2.77; 95% CI, 1.06-7.20). The results provide some evidence that women may be more susceptible to environmental tobacco smoke, as suggested by their higher adduct levels. The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure. (Less)
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- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Epidemiology Biomarkers & Prevention
- volume
- 14
- issue
- 9
- pages
- 2118 - 2124
- publisher
- American Association for Cancer Research
- external identifiers
-
- pmid:16172219
- wos:000231971400011
- scopus:27744560981
- ISSN
- 1538-7755
- DOI
- 10.1158/1055-9965/EPI-05-0150
- language
- English
- LU publication?
- yes
- id
- 2e41001a-9b59-412a-bba3-da276a4f5059 (old id 224588)
- alternative location
- http://cebp.aacrjournals.org/cgi/content/full/14/9/2118
- date added to LUP
- 2016-04-01 16:20:10
- date last changed
- 2022-01-28 19:01:17
@article{2e41001a-9b59-412a-bba3-da276a4f5059,
abstract = {{The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladder, pharynx, larynx, oral cavity, leukemias, and chronic obstructive pulmonary disease or emphysema deaths). All individuals were never smokers or ex smokers for > 10 years. 4-ABP-Hb adducts were analyzed in peripheral blood collected before the onset of the disease (median, 7 years). Overall, 4-ABP-Hb adducts were higher, although not statistically significantly so, in cases (as a whole) than controls. In the control population, high fruit and vegetable consumption significantly lowered the frequency of detectable adducts (Fisher's exact test, P = 0.025). Restricting the analysis to women, 4-ABP-Hb adducts were higher in cases than controls (Mann-Whitney P = 0.036) and the odds ratio (OR) for the presence/absence of adducts was 2.42 [95% confidence interval (95% CI), 1.18-4.981. Moreover, the association of adducts with the individual cancer types was stronger in women than in the whole study population, although statistically significant only for leukemias (OR, 2.77; 95% CI, 1.06-7.20). The results provide some evidence that women may be more susceptible to environmental tobacco smoke, as suggested by their higher adduct levels. The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure.}},
author = {{Airoldi, L and Vineis, P and Colombi, A and Olgiati, L and Dell'Osta, C and Fanelli, R and Manzi, L and Veglia, F and Autrup, H and Dunning, A and Garte, S and Hainaut, P and Hoek, G and Krzyzanowski, M and Malaveille, C and Matullo, G and Overvad, K and Tjonneland, A and Clavel-Chapelon, F and Linseisen, J and Boeing, H and Trichopoulou, A and Palli, D and Peluso, M and Krogh, V and Tumino, R and Panico, S and Bueno-De-Mesquita, HB and Peeters, PH and Lund, E and Agudo, A and Martinez, C and Dorronsoro, M and Barricarte, A and Chirlaque, MD and Quiros, JR and Berglund, Göran and Jarvholm, B and Hallmans, G and Day, NE and Allen, N and Saracci, R and Kaaks, R and Riboli, E}},
issn = {{1538-7755}},
language = {{eng}},
number = {{9}},
pages = {{2118--2124}},
publisher = {{American Association for Cancer Research}},
series = {{Cancer Epidemiology Biomarkers & Prevention}},
title = {{4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study}},
url = {{http://dx.doi.org/10.1158/1055-9965/EPI-05-0150}},
doi = {{10.1158/1055-9965/EPI-05-0150}},
volume = {{14}},
year = {{2005}},
}