Advanced

Non-Hodgkin's lymphoma in systemic lupus erythematosus

Bernatsky, S; Ramsey-Goldman, R; Rajan, R; Boivin, JF; Joseph, L; Lachance, S; Cournoyer, D; Zoma, A; Manzi, S and Ginzler, E, et al. (2005) In Annals of the Rheumatic Diseases 64(10). p.1507-1509
Abstract
Background: Recent evidence supports an association between systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL). Objectives: To describe demographic factors, subtypes, and survival of patients with SLE who develop NHL. Methods: A multi-site cohort of 9547 subjects with definite SLE was assembled. Subjects at each centre were linked to regional tumour registries to determine cancer cases occurring after SLE diagnosis. For the NHL cases ascertained, descriptive statistics were calculated, and NHL subtype frequency and median survival time of patients determined. Results: 42 cases of NHL occurred in the patients with SLE during the 76 948 patient-years of observation. The median age of patients at NHL diagnosis was 57 years.... (More)
Background: Recent evidence supports an association between systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL). Objectives: To describe demographic factors, subtypes, and survival of patients with SLE who develop NHL. Methods: A multi-site cohort of 9547 subjects with definite SLE was assembled. Subjects at each centre were linked to regional tumour registries to determine cancer cases occurring after SLE diagnosis. For the NHL cases ascertained, descriptive statistics were calculated, and NHL subtype frequency and median survival time of patients determined. Results: 42 cases of NHL occurred in the patients with SLE during the 76 948 patient-years of observation. The median age of patients at NHL diagnosis was 57 years. Thirty six (86%) of the 42 patients developing NHL were women, reflecting the female predominance of the cohort. In the patients, aggressive histological subtypes appeared to predominate, with the most commonly identified NHL subtype being diffuse large B cell ( 11 out of 21 cases for which histological subtype was available). Twenty two of the patients had died a median of 1.2 years after lymphoma diagnosis. Conclusions: These data suggest aggressive disease in patients with SLE who develop NHL. Continuing work should provide further insight into the patterns of presentation, prognosis, and aetiology of NHL in SLE. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
64
issue
10
pages
1507 - 1509
publisher
British Medical Association
external identifiers
  • wos:000231875800024
  • pmid:16162903
  • scopus:27744486101
ISSN
1468-2060
DOI
10.1136/ard.2004.034504
language
English
LU publication?
yes
id
d39a35de-a418-4add-9a69-65591dc71686 (old id 224696)
date added to LUP
2007-08-20 11:02:30
date last changed
2017-05-21 04:15:59
@article{d39a35de-a418-4add-9a69-65591dc71686,
  abstract     = {Background: Recent evidence supports an association between systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL). Objectives: To describe demographic factors, subtypes, and survival of patients with SLE who develop NHL. Methods: A multi-site cohort of 9547 subjects with definite SLE was assembled. Subjects at each centre were linked to regional tumour registries to determine cancer cases occurring after SLE diagnosis. For the NHL cases ascertained, descriptive statistics were calculated, and NHL subtype frequency and median survival time of patients determined. Results: 42 cases of NHL occurred in the patients with SLE during the 76 948 patient-years of observation. The median age of patients at NHL diagnosis was 57 years. Thirty six (86%) of the 42 patients developing NHL were women, reflecting the female predominance of the cohort. In the patients, aggressive histological subtypes appeared to predominate, with the most commonly identified NHL subtype being diffuse large B cell ( 11 out of 21 cases for which histological subtype was available). Twenty two of the patients had died a median of 1.2 years after lymphoma diagnosis. Conclusions: These data suggest aggressive disease in patients with SLE who develop NHL. Continuing work should provide further insight into the patterns of presentation, prognosis, and aetiology of NHL in SLE.},
  author       = {Bernatsky, S and Ramsey-Goldman, R and Rajan, R and Boivin, JF and Joseph, L and Lachance, S and Cournoyer, D and Zoma, A and Manzi, S and Ginzler, E and Urowitz, M and Gladman, D and Fortin, PR and Edworthy, S and Barr, S and Gordon, C and Bae, SC and Sibley, J and Steinsson, K and Nived, Ola and Sturfelt, Gunnar and St Pierre, Y and Clarke, A},
  issn         = {1468-2060},
  language     = {eng},
  number       = {10},
  pages        = {1507--1509},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Non-Hodgkin's lymphoma in systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1136/ard.2004.034504},
  volume       = {64},
  year         = {2005},
}