Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data
(2020) In Psychological Science 31(9). p.1140-1149- Abstract
Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the... (More)
Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the psychological consequences of the spouse having grown up with an AUD-affected parent (i.e., a rearing-environment effect) rather than a social-genetic effect. Findings illustrate that a spouse’s rearing-environment exposures may confer risk for AUD.
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- author
- Salvatore, Jessica E. ; Larsson Lönn, Sara LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth S.
- organization
- publishing date
- 2020-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alcohol use disorder, marriage, social-genetic effects, social-rearing-environment effects
- in
- Psychological Science
- volume
- 31
- issue
- 9
- pages
- 10 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:32816617
- scopus:85089586080
- ISSN
- 0956-7976
- DOI
- 10.1177/0956797620931542
- language
- English
- LU publication?
- yes
- id
- 224a4d92-aeb7-4bcc-8e69-eb6883cdadee
- date added to LUP
- 2020-08-28 14:44:25
- date last changed
- 2024-09-19 06:15:45
@article{224a4d92-aeb7-4bcc-8e69-eb6883cdadee, abstract = {{<p>Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the psychological consequences of the spouse having grown up with an AUD-affected parent (i.e., a rearing-environment effect) rather than a social-genetic effect. Findings illustrate that a spouse’s rearing-environment exposures may confer risk for AUD.</p>}}, author = {{Salvatore, Jessica E. and Larsson Lönn, Sara and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth S.}}, issn = {{0956-7976}}, keywords = {{alcohol use disorder; marriage; social-genetic effects; social-rearing-environment effects}}, language = {{eng}}, month = {{09}}, number = {{9}}, pages = {{1140--1149}}, publisher = {{SAGE Publications}}, series = {{Psychological Science}}, title = {{Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data}}, url = {{http://dx.doi.org/10.1177/0956797620931542}}, doi = {{10.1177/0956797620931542}}, volume = {{31}}, year = {{2020}}, }