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Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data

Salvatore, Jessica E. ; Larsson Lönn, Sara LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth S. (2020) In Psychological Science 31(9). p.1140-1149
Abstract

Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the... (More)

Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the psychological consequences of the spouse having grown up with an AUD-affected parent (i.e., a rearing-environment effect) rather than a social-genetic effect. Findings illustrate that a spouse’s rearing-environment exposures may confer risk for AUD.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol use disorder, marriage, social-genetic effects, social-rearing-environment effects
in
Psychological Science
volume
31
issue
9
pages
10 pages
publisher
SAGE Publications
external identifiers
  • scopus:85089586080
  • pmid:32816617
ISSN
0956-7976
DOI
10.1177/0956797620931542
language
English
LU publication?
yes
id
224a4d92-aeb7-4bcc-8e69-eb6883cdadee
date added to LUP
2020-08-28 14:44:25
date last changed
2024-05-15 18:22:46
@article{224a4d92-aeb7-4bcc-8e69-eb6883cdadee,
  abstract     = {{<p>Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse’s AUD status, or contact with the spouse’s parents; and (c) this increased risk reflected the psychological consequences of the spouse having grown up with an AUD-affected parent (i.e., a rearing-environment effect) rather than a social-genetic effect. Findings illustrate that a spouse’s rearing-environment exposures may confer risk for AUD.</p>}},
  author       = {{Salvatore, Jessica E. and Larsson Lönn, Sara and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth S.}},
  issn         = {{0956-7976}},
  keywords     = {{alcohol use disorder; marriage; social-genetic effects; social-rearing-environment effects}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{1140--1149}},
  publisher    = {{SAGE Publications}},
  series       = {{Psychological Science}},
  title        = {{Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data}},
  url          = {{http://dx.doi.org/10.1177/0956797620931542}},
  doi          = {{10.1177/0956797620931542}},
  volume       = {{31}},
  year         = {{2020}},
}