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Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty

Saeed, A. ; Herlitz, H. ; Nowakowska-Fortuna, E. ; Nilsson, U. ; Alhadad, Alaa LU ; Jensen, G. ; Mattiasson, Ingrid LU ; Lindblad, Bengt LU ; Gottsäter, Anders LU and Guron, G. (2011) In Kidney & Blood Pressure Research 34(6). p.396-403
Abstract
Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were... (More)
Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelin-1, Oxidative stress, Renal angioplasty, Renal artery, stenosis, Renovascular hypertension
in
Kidney & Blood Pressure Research
volume
34
issue
6
pages
396 - 403
publisher
Karger
external identifiers
  • wos:000297128400004
  • scopus:79958765639
  • pmid:21677436
ISSN
1423-0143
DOI
10.1159/000328732
language
English
LU publication?
yes
id
c71afbe7-3867-4d7d-8827-e204bc9a8509 (old id 2252684)
date added to LUP
2016-04-01 14:17:37
date last changed
2022-03-21 23:17:38
@article{c71afbe7-3867-4d7d-8827-e204bc9a8509,
  abstract     = {{Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel}},
  author       = {{Saeed, A. and Herlitz, H. and Nowakowska-Fortuna, E. and Nilsson, U. and Alhadad, Alaa and Jensen, G. and Mattiasson, Ingrid and Lindblad, Bengt and Gottsäter, Anders and Guron, G.}},
  issn         = {{1423-0143}},
  keywords     = {{Endothelin-1; Oxidative stress; Renal angioplasty; Renal artery; stenosis; Renovascular hypertension}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{396--403}},
  publisher    = {{Karger}},
  series       = {{Kidney & Blood Pressure Research}},
  title        = {{Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty}},
  url          = {{http://dx.doi.org/10.1159/000328732}},
  doi          = {{10.1159/000328732}},
  volume       = {{34}},
  year         = {{2011}},
}