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Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty

Saeed, A.; Herlitz, H.; Nowakowska-Fortuna, E.; Nilsson, U.; Alhadad, Alaa LU ; Jensen, G.; Mattiasson, Ingrid LU ; Lindblad, Bengt LU ; Gottsäter, Anders LU and Guron, G. (2011) In Kidney & Blood Pressure Research 34(6). p.396-403
Abstract
Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were... (More)
Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelin-1, Oxidative stress, Renal angioplasty, Renal artery, stenosis, Renovascular hypertension
in
Kidney & Blood Pressure Research
volume
34
issue
6
pages
396 - 403
publisher
Karger
external identifiers
  • wos:000297128400004
  • scopus:79958765639
ISSN
1423-0143
DOI
10.1159/000328732
language
English
LU publication?
yes
id
c71afbe7-3867-4d7d-8827-e204bc9a8509 (old id 2252684)
date added to LUP
2012-01-02 07:57:17
date last changed
2017-01-01 06:09:57
@article{c71afbe7-3867-4d7d-8827-e204bc9a8509,
  abstract     = {Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel},
  author       = {Saeed, A. and Herlitz, H. and Nowakowska-Fortuna, E. and Nilsson, U. and Alhadad, Alaa and Jensen, G. and Mattiasson, Ingrid and Lindblad, Bengt and Gottsäter, Anders and Guron, G.},
  issn         = {1423-0143},
  keyword      = {Endothelin-1,Oxidative stress,Renal angioplasty,Renal artery,stenosis,Renovascular hypertension},
  language     = {eng},
  number       = {6},
  pages        = {396--403},
  publisher    = {Karger},
  series       = {Kidney & Blood Pressure Research},
  title        = {Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty},
  url          = {http://dx.doi.org/10.1159/000328732},
  volume       = {34},
  year         = {2011},
}