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Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway

Haugen, Trine B.; Tefre, Toril; Malm, Gunilla LU ; Jönsson, Bo A LU ; Rylander, Lars LU ; Hagmar, Lars LU ; Bjorsvik, Cathrine; Henrichsen, Trine; Saether, Thomas and Figenschau, Yngve, et al. (2011) In Reproductive Toxicology 32(3). p.261-267
Abstract
Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p = 0.27) or sperm parameters. However, the levels of AV-ODE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p = 0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong... (More)
Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p = 0.27) or sperm parameters. However, the levels of AV-ODE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p = 0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality. (C) 2011 Elsevier Inc. All rights reserved. (Less)
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keywords
Reproductive hormones, Sperm characteristics, POPs, CB-153, p '-DDE, p, Norway, Geographical difference, Male
in
Reproductive Toxicology
volume
32
issue
3
pages
261 - 267
publisher
Elsevier
external identifiers
  • wos:000296935100002
  • scopus:80755139556
ISSN
1873-1708
DOI
10.1016/j.reprotox.2011.06.072
language
English
LU publication?
yes
id
e79babef-a711-4482-b649-d12b05a416a5 (old id 2253031)
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2012-01-02 07:58:36
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2017-07-09 04:10:59
@article{e79babef-a711-4482-b649-d12b05a416a5,
  abstract     = {Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p = 0.27) or sperm parameters. However, the levels of AV-ODE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p = 0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality. (C) 2011 Elsevier Inc. All rights reserved.},
  author       = {Haugen, Trine B. and Tefre, Toril and Malm, Gunilla and Jönsson, Bo A and Rylander, Lars and Hagmar, Lars and Bjorsvik, Cathrine and Henrichsen, Trine and Saether, Thomas and Figenschau, Yngve and Giwercman, Aleksander},
  issn         = {1873-1708},
  keyword      = {Reproductive hormones,Sperm characteristics,POPs,CB-153,p '-DDE,p,Norway,Geographical difference,Male},
  language     = {eng},
  number       = {3},
  pages        = {261--267},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2011.06.072},
  volume       = {32},
  year         = {2011},
}