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Aspects of Tumour Demarcation In Rats By Means of Laser-induced Fluorescence and Hematoporphyrin Derivatives

Andersson-Engels, Stefan LU ; Ankerst, J; Montan, Sune; Svanberg, Katarina LU and Svanberg, Sune LU (1988) In Lasers in Medical Science 3(4). p.239-248
Abstract
The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporophyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the tumor tumour-seeking agents Photofrin (haematoporphyrin deriative) and Photofrin II (dihaematoporphyrin ether) we have performed a comparative study on rat tissues. The results suggest that Photofrin is at least as good as the therapeutically more potent agent Photofrin II. A linear relation between drug dose and recorded prophyrin fluorescence intensity was also found. Using not only the porphyrin... (More)
The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporophyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the tumor tumour-seeking agents Photofrin (haematoporphyrin deriative) and Photofrin II (dihaematoporphyrin ether) we have performed a comparative study on rat tissues. The results suggest that Photofrin is at least as good as the therapeutically more potent agent Photofrin II. A linear relation between drug dose and recorded prophyrin fluorescence intensity was also found. Using not only the porphyrin fluorescence, but also natural tissue autofluorescence, better tumour demarcation is observed when utilizing an excitation wavelength shorter than the porphyrin excitation peak at 405 nm. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lasers in Medical Science
volume
3
issue
4
pages
239 - 248
publisher
Springer
external identifiers
  • Scopus:77951506197
ISSN
0268-8921
DOI
10.1007/BF02593819
language
English
LU publication?
yes
id
711a7290-465a-4532-8877-c931c263c7d2 (old id 2257248)
date added to LUP
2012-02-24 15:20:04
date last changed
2017-01-01 07:52:26
@article{711a7290-465a-4532-8877-c931c263c7d2,
  abstract     = {The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporophyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the tumor tumour-seeking agents Photofrin (haematoporphyrin deriative) and Photofrin II (dihaematoporphyrin ether) we have performed a comparative study on rat tissues. The results suggest that Photofrin is at least as good as the therapeutically more potent agent Photofrin II. A linear relation between drug dose and recorded prophyrin fluorescence intensity was also found. Using not only the porphyrin fluorescence, but also natural tissue autofluorescence, better tumour demarcation is observed when utilizing an excitation wavelength shorter than the porphyrin excitation peak at 405 nm.},
  author       = {Andersson-Engels, Stefan and Ankerst, J and Montan, Sune and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0268-8921},
  language     = {eng},
  number       = {4},
  pages        = {239--248},
  publisher    = {Springer},
  series       = {Lasers in Medical Science},
  title        = {Aspects of Tumour Demarcation In Rats By Means of Laser-induced Fluorescence and Hematoporphyrin Derivatives},
  url          = {http://dx.doi.org/10.1007/BF02593819},
  volume       = {3},
  year         = {1988},
}