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Multi-colour fluorescence imaging in connection with photodynamic therapy of delta-amino levulinic acid (ALA) sensitised skin malignancies

Andersson-Engels, Stefan LU ; Berg, R; Svanberg, Katarina LU and Svanberg, Sune LU (1995) In Bioimaging 3(3). p.134-143
Abstract
Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image... (More)
Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tissue diagnostics, fluorescence spectroscopy, imaging, skin cancer, photosensitiser, ALA
in
Bioimaging
volume
3
issue
3
pages
134 - 143
publisher
IOP Publishing
external identifiers
  • scopus:0029555295
ISSN
0966-9051
DOI
10.1002/1361-6374(199509)3:3<134::AID-BIO4>3.0.CO;2-1
language
English
LU publication?
yes
id
7697183a-6716-4b68-9431-89e871d2cde6 (old id 2257260)
date added to LUP
2012-02-27 22:36:37
date last changed
2017-01-08 04:12:21
@article{7697183a-6716-4b68-9431-89e871d2cde6,
  abstract     = {Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel.},
  author       = {Andersson-Engels, Stefan and Berg, R and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0966-9051},
  keyword      = {tissue diagnostics,fluorescence spectroscopy,imaging,skin cancer,photosensitiser,ALA},
  language     = {eng},
  number       = {3},
  pages        = {134--143},
  publisher    = {IOP Publishing},
  series       = {Bioimaging},
  title        = {Multi-colour fluorescence imaging in connection with photodynamic therapy of delta-amino levulinic acid (ALA) sensitised skin malignancies},
  url          = {http://dx.doi.org/10.1002/1361-6374(199509)3:3<134::AID-BIO4>3.0.CO;2-1},
  volume       = {3},
  year         = {1995},
}