Multi-colour fluorescence imaging in connection with photodynamic therapy of delta-amino levulinic acid (ALA) sensitised skin malignancies
(1995) In Bioimaging 3(3). p.134-143- Abstract
- Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image... (More)
- Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2257260
- author
- Andersson-Engels, Stefan LU ; Berg, R ; Svanberg, Katarina LU and Svanberg, Sune LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tissue diagnostics, fluorescence spectroscopy, imaging, skin cancer, photosensitiser, ALA
- in
- Bioimaging
- volume
- 3
- issue
- 3
- pages
- 134 - 143
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0029555295
- ISSN
- 0966-9051
- DOI
- 10.1002/1361-6374(199509)3:3<134::AID-BIO4>3.0.CO;2-1
- language
- English
- LU publication?
- yes
- id
- 7697183a-6716-4b68-9431-89e871d2cde6 (old id 2257260)
- date added to LUP
- 2016-04-01 12:30:48
- date last changed
- 2025-01-02 20:39:33
@article{7697183a-6716-4b68-9431-89e871d2cde6,
abstract = {{Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel.}},
author = {{Andersson-Engels, Stefan and Berg, R and Svanberg, Katarina and Svanberg, Sune}},
issn = {{0966-9051}},
keywords = {{tissue diagnostics; fluorescence spectroscopy; imaging; skin cancer; photosensitiser; ALA}},
language = {{eng}},
number = {{3}},
pages = {{134--143}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Bioimaging}},
title = {{Multi-colour fluorescence imaging in connection with photodynamic therapy of delta-amino levulinic acid (ALA) sensitised skin malignancies}},
url = {{https://lup.lub.lu.se/search/files/2953699/2365649.pdf}},
doi = {{10.1002/1361-6374(199509)3:3<134::AID-BIO4>3.0.CO;2-1}},
volume = {{3}},
year = {{1995}},
}