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Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative

Andersson-Engels, Stefan LU ; Brun, A; Kjellén, E; Salford, L.G; Strömblad, L.-G; Svanberg, Katarina LU and Svanberg, Sune LU (1989) In Lasers in Medical Science 4(4). p.241-249
Abstract
Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medicine
in
Lasers in Medical Science
volume
4
issue
4
pages
241 - 249
publisher
Springer
external identifiers
  • scopus:0024955528
ISSN
0268-8921
language
English
LU publication?
yes
id
cd1e6b5c-79a6-43a9-bf68-6f5b04a3c10a (old id 2257267)
alternative location
http://dx.doi.org/10.1007/BF02032454
date added to LUP
2012-02-27 22:29:47
date last changed
2017-07-30 04:45:37
@article{cd1e6b5c-79a6-43a9-bf68-6f5b04a3c10a,
  abstract     = {Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.},
  author       = {Andersson-Engels, Stefan and Brun, A and Kjellén, E and Salford, L.G and Strömblad, L.-G and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0268-8921},
  keyword      = {Medicine},
  language     = {eng},
  number       = {4},
  pages        = {241--249},
  publisher    = {Springer},
  series       = {Lasers in Medical Science},
  title        = {Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative},
  volume       = {4},
  year         = {1989},
}