Advanced

Clinical recording of laser-induced fluorescence spectra for evaluation of tumour demarcation feasibility in selected clinical specialities

Andersson-Engels, Stefan LU ; Elner, A; Johansson, Jonas LU ; Karlsson, S; Salford, L; Stromblad, L; Svanberg, Katarina LU and Svanberg, Sune LU (1991) In Lasers in Medical Science 6(4). p.415-424
Abstract
Laser-induced autofluorescence spectra from humans were recorded in vivo at three different clinics in a study aimed at investigating the capability of this method to discriminate between malignant tumours and normal surrounding tissues. For the recordings a mobile trolley with the necessary equipment was constructed for use in an examination room or in an operating theatre environment. Laser light was guided through a 600m optical fibre to the target tissue. The fluorescence from the excited tissue was collected with the same fibre and was fed to an optical multichannel analyser. Two excitation wavelengths were used (337 and 405 nm) in order to optimize the fluorescence signals in two interesting wavelength regions (380–500 and 550–700... (More)
Laser-induced autofluorescence spectra from humans were recorded in vivo at three different clinics in a study aimed at investigating the capability of this method to discriminate between malignant tumours and normal surrounding tissues. For the recordings a mobile trolley with the necessary equipment was constructed for use in an examination room or in an operating theatre environment. Laser light was guided through a 600m optical fibre to the target tissue. The fluorescence from the excited tissue was collected with the same fibre and was fed to an optical multichannel analyser. Two excitation wavelengths were used (337 and 405 nm) in order to optimize the fluorescence signals in two interesting wavelength regions (380–500 and 550–700 nm). Oral and oropharyngeal tumours excited with 405 nm light contained detectable endogenous porphyrins and were in this way discriminated from the normal mucosa. Astrocytoma grade III–IV fluorescence different from that of normal brain tissue, while tumours in the bronchial tree were not detectable using the spectral shape of the pure tissue autofluorescence. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medicine
in
Lasers in Medical Science
volume
6
issue
4
pages
415 - 424
publisher
Springer
external identifiers
  • scopus:0026337975
ISSN
0268-8921
DOI
10.1007/BF02042464
language
English
LU publication?
yes
id
4af4f239-5503-43c0-8d2b-9347f84e990d (old id 2257289)
date added to LUP
2012-02-24 00:21:34
date last changed
2017-02-19 04:06:52
@article{4af4f239-5503-43c0-8d2b-9347f84e990d,
  abstract     = {Laser-induced autofluorescence spectra from humans were recorded in vivo at three different clinics in a study aimed at investigating the capability of this method to discriminate between malignant tumours and normal surrounding tissues. For the recordings a mobile trolley with the necessary equipment was constructed for use in an examination room or in an operating theatre environment. Laser light was guided through a 600m optical fibre to the target tissue. The fluorescence from the excited tissue was collected with the same fibre and was fed to an optical multichannel analyser. Two excitation wavelengths were used (337 and 405 nm) in order to optimize the fluorescence signals in two interesting wavelength regions (380–500 and 550–700 nm). Oral and oropharyngeal tumours excited with 405 nm light contained detectable endogenous porphyrins and were in this way discriminated from the normal mucosa. Astrocytoma grade III–IV fluorescence different from that of normal brain tissue, while tumours in the bronchial tree were not detectable using the spectral shape of the pure tissue autofluorescence.},
  author       = {Andersson-Engels, Stefan and Elner, A and Johansson, Jonas and Karlsson, S and Salford, L and Stromblad, L and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0268-8921},
  keyword      = {Medicine},
  language     = {eng},
  number       = {4},
  pages        = {415--424},
  publisher    = {Springer},
  series       = {Lasers in Medical Science},
  title        = {Clinical recording of laser-induced fluorescence spectra for evaluation of tumour demarcation feasibility in selected clinical specialities},
  url          = {http://dx.doi.org/10.1007/BF02042464},
  volume       = {6},
  year         = {1991},
}