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Laser-induced fluorescence used in localizing atherosclerotic lesions

Andersson-Engels, Stefan LU ; Gustafson, A; Johansson, Jonas LU ; Stenram, U; Svanberg, Katarina LU and Svanberg, Sune LU (1989) In Lasers in Medical Science 4(3). p.171-181
Abstract
We have investigated laser-induced fluorescence frompost mortem human arteries in order to find spectroscopic properties allowing discrimination between normal and atherosclerotic vessel wall. A pulsed nitrogen laser emitting light at a wavelength of 337.1 nm was used as an excitation source. The fluorescence spectrum from 370 to 700 nm was captured and analysed by an optical multichannel analyser. Dimensionless contrast functions were formed by using characteristic spectral features at 390, 415, 480, 580 and 600 nm. All samples were investigated in scans across a region where normal as well as diseased vessel wall appeared. The types of plaque were histopathologically divided into four groups, of which three could be singled out using one... (More)
We have investigated laser-induced fluorescence frompost mortem human arteries in order to find spectroscopic properties allowing discrimination between normal and atherosclerotic vessel wall. A pulsed nitrogen laser emitting light at a wavelength of 337.1 nm was used as an excitation source. The fluorescence spectrum from 370 to 700 nm was captured and analysed by an optical multichannel analyser. Dimensionless contrast functions were formed by using characteristic spectral features at 390, 415, 480, 580 and 600 nm. All samples were investigated in scans across a region where normal as well as diseased vessel wall appeared. The types of plaque were histopathologically divided into four groups, of which three could be singled out using one or more of our spectroscopic criteria. We also investigated the different layers of the normal and diseased vessel wall in order to determine the various contributions to the fluorescence signal. Furthermore, plasma emission spectra were recorded while ablating the normal as well as the diseased vessel wall with an excimer laser, emitting radiation at 308 nm, thus detecting the change in spectral characteristics during the ablation process down into deeper layers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medicine
in
Lasers in Medical Science
volume
4
issue
3
pages
171 - 181
publisher
Springer
external identifiers
  • scopus:0024425806
ISSN
0268-8921
DOI
10.1007/BF02032432
language
English
LU publication?
yes
id
a8734410-9ecc-4420-a4d9-8ba9fc4b1cc9 (old id 2257302)
date added to LUP
2012-02-27 22:24:38
date last changed
2017-07-30 04:30:14
@article{a8734410-9ecc-4420-a4d9-8ba9fc4b1cc9,
  abstract     = {We have investigated laser-induced fluorescence frompost mortem human arteries in order to find spectroscopic properties allowing discrimination between normal and atherosclerotic vessel wall. A pulsed nitrogen laser emitting light at a wavelength of 337.1 nm was used as an excitation source. The fluorescence spectrum from 370 to 700 nm was captured and analysed by an optical multichannel analyser. Dimensionless contrast functions were formed by using characteristic spectral features at 390, 415, 480, 580 and 600 nm. All samples were investigated in scans across a region where normal as well as diseased vessel wall appeared. The types of plaque were histopathologically divided into four groups, of which three could be singled out using one or more of our spectroscopic criteria. We also investigated the different layers of the normal and diseased vessel wall in order to determine the various contributions to the fluorescence signal. Furthermore, plasma emission spectra were recorded while ablating the normal as well as the diseased vessel wall with an excimer laser, emitting radiation at 308 nm, thus detecting the change in spectral characteristics during the ablation process down into deeper layers.},
  author       = {Andersson-Engels, Stefan and Gustafson, A and Johansson, Jonas and Stenram, U and Svanberg, Katarina and Svanberg, Sune},
  issn         = {0268-8921},
  keyword      = {Medicine},
  language     = {eng},
  number       = {3},
  pages        = {171--181},
  publisher    = {Springer},
  series       = {Lasers in Medical Science},
  title        = {Laser-induced fluorescence used in localizing atherosclerotic lesions},
  url          = {http://dx.doi.org/10.1007/BF02032432},
  volume       = {4},
  year         = {1989},
}