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In vivo fluorescence imaging for tissue diagnostics

Andersson-Engels, Stefan LU ; af Klinteberg, C; Svanberg, Katarina LU and Svanberg, Sune LU (1997) In Physics in Medicine and Biology 42(5). p.815-824
Abstract
Non-invasive fluorescence imaging has the potential to provide in vivo diagnostic information for many clinical specialities. Techniques have been developed over the years for simple ocular observations following UV excitation to sophisticated spectroscopic imaging using advanced equipment. Much of the impetus for research on fluorescence imaging for tissue diagnostics has come from parallel developments in photodynamic therapy of malignant lesions with fluorescent photosensitizers. However, the fluorescence of endogenous molecules (tissue autofluorescence) also plays an important role in most applications. In this paper, the possibilities of imaging tissues using fluorescence spectroscopy as a mean of tissue characterization are... (More)
Non-invasive fluorescence imaging has the potential to provide in vivo diagnostic information for many clinical specialities. Techniques have been developed over the years for simple ocular observations following UV excitation to sophisticated spectroscopic imaging using advanced equipment. Much of the impetus for research on fluorescence imaging for tissue diagnostics has come from parallel developments in photodynamic therapy of malignant lesions with fluorescent photosensitizers. However, the fluorescence of endogenous molecules (tissue autofluorescence) also plays an important role in most applications. In this paper, the possibilities of imaging tissues using fluorescence spectroscopy as a mean of tissue characterization are discussed. The various imaging techniques for extracting diagnostic information suggested in the literature are reviewed. The development of exogenous fluorophores for this purpose is also presented. Finally, the present status of clinical evaluation and future directions are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
42
issue
5
pages
815 - 824
publisher
IOP Publishing
external identifiers
  • scopus:0011294774
ISSN
1361-6560
DOI
10.1088/0031-9155/42/5/006
language
English
LU publication?
yes
id
f8ed9265-a2ca-4c72-9ed2-16715b64d7d5 (old id 2257323)
date added to LUP
2012-02-24 09:33:59
date last changed
2017-07-23 04:51:17
@article{f8ed9265-a2ca-4c72-9ed2-16715b64d7d5,
  abstract     = {Non-invasive fluorescence imaging has the potential to provide in vivo diagnostic information for many clinical specialities. Techniques have been developed over the years for simple ocular observations following UV excitation to sophisticated spectroscopic imaging using advanced equipment. Much of the impetus for research on fluorescence imaging for tissue diagnostics has come from parallel developments in photodynamic therapy of malignant lesions with fluorescent photosensitizers. However, the fluorescence of endogenous molecules (tissue autofluorescence) also plays an important role in most applications. In this paper, the possibilities of imaging tissues using fluorescence spectroscopy as a mean of tissue characterization are discussed. The various imaging techniques for extracting diagnostic information suggested in the literature are reviewed. The development of exogenous fluorophores for this purpose is also presented. Finally, the present status of clinical evaluation and future directions are discussed.},
  author       = {Andersson-Engels, Stefan and af Klinteberg, C and Svanberg, Katarina and Svanberg, Sune},
  issn         = {1361-6560},
  language     = {eng},
  number       = {5},
  pages        = {815--824},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {In vivo fluorescence imaging for tissue diagnostics},
  url          = {http://dx.doi.org/10.1088/0031-9155/42/5/006},
  volume       = {42},
  year         = {1997},
}