Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths
(2001) In Applied Optics 40(7). p.1155-1164- Abstract
- We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean... (More)
- We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements. (C) 2001 Optical Society of America (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2257813
- author
- Dam, J. S ; Pedersen, C. B ; Dalgaard, T ; Fabricius, P. E ; Aruna, P and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Optics
- volume
- 40
- issue
- 7
- pages
- 1155 - 1164
- publisher
- Optical Society of America
- external identifiers
-
- scopus:0000196465
- ISSN
- 2155-3165
- DOI
- 10.1364/AO.40.001155
- language
- English
- LU publication?
- yes
- id
- 0816346e-d176-4e68-876f-c78c54f72c9b (old id 2257813)
- date added to LUP
- 2016-04-04 08:54:23
- date last changed
- 2022-01-29 07:34:14
@article{0816346e-d176-4e68-876f-c78c54f72c9b,
abstract = {{We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements. (C) 2001 Optical Society of America}},
author = {{Dam, J. S and Pedersen, C. B and Dalgaard, T and Fabricius, P. E and Aruna, P and Andersson-Engels, Stefan}},
issn = {{2155-3165}},
language = {{eng}},
number = {{7}},
pages = {{1155--1164}},
publisher = {{Optical Society of America}},
series = {{Applied Optics}},
title = {{Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths}},
url = {{https://lup.lub.lu.se/search/files/5204842/2297127.pdf}},
doi = {{10.1364/AO.40.001155}},
volume = {{40}},
year = {{2001}},
}