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Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths

Dam, J. S; Pedersen, C. B; Dalgaard, T; Fabricius, P. E; Aruna, P and Andersson-Engels, Stefan LU (2001) In Applied Optics 40(7). p.1155-1164
Abstract
We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean... (More)
We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements. (C) 2001 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
40
issue
7
pages
1155 - 1164
publisher
OSA
external identifiers
  • scopus:0000196465
ISSN
2155-3165
DOI
10.1364/AO.40.001155
language
English
LU publication?
yes
id
0816346e-d176-4e68-876f-c78c54f72c9b (old id 2257813)
date added to LUP
2012-02-22 23:47:38
date last changed
2018-03-11 04:19:11
@article{0816346e-d176-4e68-876f-c78c54f72c9b,
  abstract     = {We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements. (C) 2001 Optical Society of America},
  author       = {Dam, J. S and Pedersen, C. B and Dalgaard, T and Fabricius, P. E and Aruna, P and Andersson-Engels, Stefan},
  issn         = {2155-3165},
  language     = {eng},
  number       = {7},
  pages        = {1155--1164},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths},
  url          = {http://dx.doi.org/10.1364/AO.40.001155},
  volume       = {40},
  year         = {2001},
}