Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues
(1997) In Cancer Letters 112(2). p.225-231- Abstract
- Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in... (More)
- Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2258387
- author
- Heyerdahl, H ; Wang, I ; Liu, D. L ; Berg, R ; Andersson-Engels, Stefan LU ; Peng, Q ; Moan, J ; Svanberg, Sune LU and Svanberg, Katarina LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Letters
- volume
- 112
- issue
- 2
- pages
- 225 - 231
- publisher
- Elsevier
- external identifiers
-
- scopus:0031590964
- ISSN
- 1872-7980
- DOI
- 10.1016/S0304-3835(96)04576-4
- language
- English
- LU publication?
- yes
- id
- abb86023-6c10-4336-8df0-2591f85cf939 (old id 2258387)
- date added to LUP
- 2016-04-04 09:05:54
- date last changed
- 2022-01-29 08:17:21
@article{abb86023-6c10-4336-8df0-2591f85cf939,
abstract = {{Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd.}},
author = {{Heyerdahl, H and Wang, I and Liu, D. L and Berg, R and Andersson-Engels, Stefan and Peng, Q and Moan, J and Svanberg, Sune and Svanberg, Katarina}},
issn = {{1872-7980}},
language = {{eng}},
number = {{2}},
pages = {{225--231}},
publisher = {{Elsevier}},
series = {{Cancer Letters}},
title = {{Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues}},
url = {{https://lup.lub.lu.se/search/files/5231087/2297277.pdf}},
doi = {{10.1016/S0304-3835(96)04576-4}},
volume = {{112}},
year = {{1997}},
}