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Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

Heyerdahl, H; Wang, I; Liu, D. L; Berg, R; Andersson-Engels, Stefan LU ; Peng, Q; Moan, J; Svanberg, Sune LU and Svanberg, Katarina LU (1997) In Cancer Letters 112(2). p.225-231
Abstract
Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in... (More)
Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Letters
volume
112
issue
2
pages
225 - 231
publisher
Elsevier
external identifiers
  • scopus:0031590964
ISSN
1872-7980
DOI
10.1016/S0304-3835(96)04576-4
language
English
LU publication?
yes
id
abb86023-6c10-4336-8df0-2591f85cf939 (old id 2258387)
date added to LUP
2012-02-20 23:41:33
date last changed
2017-01-01 07:42:30
@article{abb86023-6c10-4336-8df0-2591f85cf939,
  abstract     = {Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd.},
  author       = {Heyerdahl, H and Wang, I and Liu, D. L and Berg, R and Andersson-Engels, Stefan and Peng, Q and Moan, J and Svanberg, Sune and Svanberg, Katarina},
  issn         = {1872-7980},
  language     = {eng},
  number       = {2},
  pages        = {225--231},
  publisher    = {Elsevier},
  series       = {Cancer Letters},
  title        = {Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues},
  url          = {http://dx.doi.org/10.1016/S0304-3835(96)04576-4},
  volume       = {112},
  year         = {1997},
}