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Laser-induced Fluorescence In Malignant and Normal Tissue In Mice Injected With 2 Different Carotenoporphyrins

Nilsson, H; Johansson, Jonas LU ; Svanberg, Katarina LU ; Svanberg, Sune LU ; Jori, G; Reddi, E; Segalla, A; Gust, D; Moore, A. L and Moore, T. A (1994) In British Journal of Cancer 70(5). p.873-879
Abstract
Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at... (More)
Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
70
issue
5
pages
873 - 879
publisher
Nature Publishing Group
external identifiers
  • scopus:0028154913
ISSN
1532-1827
DOI
10.1038/bjc.1994.413
language
English
LU publication?
yes
id
f530e9ba-dc06-480d-8721-8c2cac0f8a05 (old id 2259051)
date added to LUP
2012-02-17 22:47:14
date last changed
2017-11-19 04:17:50
@article{f530e9ba-dc06-480d-8721-8c2cac0f8a05,
  abstract     = {Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2.},
  author       = {Nilsson, H and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune and Jori, G and Reddi, E and Segalla, A and Gust, D and Moore, A. L and Moore, T. A},
  issn         = {1532-1827},
  language     = {eng},
  number       = {5},
  pages        = {873--879},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Laser-induced Fluorescence In Malignant and Normal Tissue In Mice Injected With 2 Different Carotenoporphyrins},
  url          = {http://dx.doi.org/10.1038/bjc.1994.413},
  volume       = {70},
  year         = {1994},
}