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Absorption-spectroscopy In Tissue-simulating Materials - A Theoretical and Experimental-study of Photon Paths

Patterson, M. S; Andersson-Engels, Stefan LU ; Wilson, B. C and Osei, E. K (1995) In Applied Optics 34(1). p.22-30
Abstract
A diffusion model of noninvasive absorption spectroscopy was used to determine how the change in signal resulting from a point absorber depends on the position of that absorber relative to the source and detector. This is equivalent to calculating the relative probability that a photon will visit a certain location in tissue before its detection. Experimental mapping of the point-target response in tissue-simulating materials confirmed the accuracy of the model. For steady-state spectroscopy a simple relation was derived between the mean depth visited by detected photons, the source-detector separation, and the optical penetration depth. It was also demonstrated theoretically that combining a pulsed source with time-gated detection... (More)
A diffusion model of noninvasive absorption spectroscopy was used to determine how the change in signal resulting from a point absorber depends on the position of that absorber relative to the source and detector. This is equivalent to calculating the relative probability that a photon will visit a certain location in tissue before its detection. Experimental mapping of the point-target response in tissue-simulating materials confirmed the accuracy of the model. For steady-state spectroscopy a simple relation was derived between the mean depth visited by detected photons, the source-detector separation, and the optical penetration depth. It was also demonstrated theoretically that combining a pulsed source with time-gated detection provides additional control over the spatial distribution of the photon-visit probability. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
34
issue
1
pages
22 - 30
publisher
OSA
external identifiers
  • scopus:0029185321
ISSN
2155-3165
DOI
10.1364/AO.34.000022
language
English
LU publication?
yes
id
670d0b38-afb0-4ff7-b04e-2bb38aaf655f (old id 2259122)
date added to LUP
2012-02-27 10:25:48
date last changed
2017-10-22 04:54:19
@article{670d0b38-afb0-4ff7-b04e-2bb38aaf655f,
  abstract     = {A diffusion model of noninvasive absorption spectroscopy was used to determine how the change in signal resulting from a point absorber depends on the position of that absorber relative to the source and detector. This is equivalent to calculating the relative probability that a photon will visit a certain location in tissue before its detection. Experimental mapping of the point-target response in tissue-simulating materials confirmed the accuracy of the model. For steady-state spectroscopy a simple relation was derived between the mean depth visited by detected photons, the source-detector separation, and the optical penetration depth. It was also demonstrated theoretically that combining a pulsed source with time-gated detection provides additional control over the spatial distribution of the photon-visit probability.},
  author       = {Patterson, M. S and Andersson-Engels, Stefan and Wilson, B. C and Osei, E. K},
  issn         = {2155-3165},
  language     = {eng},
  number       = {1},
  pages        = {22--30},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {Absorption-spectroscopy In Tissue-simulating Materials - A Theoretical and Experimental-study of Photon Paths},
  url          = {http://dx.doi.org/10.1364/AO.34.000022},
  volume       = {34},
  year         = {1995},
}