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A mathematical model for predicting the temperature distribution in laser-induced hyperthermia. Experimental evaluation and applications

Sturesson, C and Andersson-Engels, Stefan LU (1995) In Physics in Medicine and Biology 40(12). p.2037-2052
Abstract
A time-dependent mathematical model for the heat transfer in laser-induced hyperthermia has been developed. The model calculates the temperature distribution in surface-irradiated tissues. Good agreement was found between the predictions of the model and in vitro experimental results obtained for bovine liver irradiated with an expanded beam from a Nd:YAG laser. Surface evaporation of water was included in the model and experimentally verified. The discrepancy between the measured and the calculated rise in temperature at three different depths on the axis of symmetry of the irradiating beam was found to be less than 5% after 15 min of irradiation. When irradiating in air and not accounting for the surface evaporation in the model, the... (More)
A time-dependent mathematical model for the heat transfer in laser-induced hyperthermia has been developed. The model calculates the temperature distribution in surface-irradiated tissues. Good agreement was found between the predictions of the model and in vitro experimental results obtained for bovine liver irradiated with an expanded beam from a Nd:YAG laser. Surface evaporation of water was included in the model and experimentally verified. The discrepancy between the measured and the calculated rise in temperature at three different depths on the axis of symmetry of the irradiating beam was found to be less than 5% after 15 min of irradiation. When irradiating in air and not accounting for the surface evaporation in the model, the accuracy of the model predictions was only 75-80%. The model was then used to investigate the influence of surface evaporation of water on the total temperature distribution theoretically in a clinically relevant case. From the numerical simulations, it was shown that, simply by providing a moistened liver surface, the maximum steady-state temperature could be forced into the tissue to a depth of 4 mm. It was also shown that, by employing the numerical model during the initial phase of hyperthermia treatment, overshooting of the temperature during the transient thermal build-up time could be prevented. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
40
issue
12
pages
2037 - 2052
publisher
IOP Publishing
external identifiers
  • scopus:0029610775
ISSN
1361-6560
DOI
10.1088/0031-9155/40/12/003
language
English
LU publication?
yes
id
27f3d5c4-5070-48a7-9021-aca628b9dd89 (old id 2259438)
date added to LUP
2012-02-09 21:15:08
date last changed
2017-11-19 04:18:01
@article{27f3d5c4-5070-48a7-9021-aca628b9dd89,
  abstract     = {A time-dependent mathematical model for the heat transfer in laser-induced hyperthermia has been developed. The model calculates the temperature distribution in surface-irradiated tissues. Good agreement was found between the predictions of the model and in vitro experimental results obtained for bovine liver irradiated with an expanded beam from a Nd:YAG laser. Surface evaporation of water was included in the model and experimentally verified. The discrepancy between the measured and the calculated rise in temperature at three different depths on the axis of symmetry of the irradiating beam was found to be less than 5% after 15 min of irradiation. When irradiating in air and not accounting for the surface evaporation in the model, the accuracy of the model predictions was only 75-80%. The model was then used to investigate the influence of surface evaporation of water on the total temperature distribution theoretically in a clinically relevant case. From the numerical simulations, it was shown that, simply by providing a moistened liver surface, the maximum steady-state temperature could be forced into the tissue to a depth of 4 mm. It was also shown that, by employing the numerical model during the initial phase of hyperthermia treatment, overshooting of the temperature during the transient thermal build-up time could be prevented.},
  author       = {Sturesson, C and Andersson-Engels, Stefan},
  issn         = {1361-6560},
  language     = {eng},
  number       = {12},
  pages        = {2037--2052},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {A mathematical model for predicting the temperature distribution in laser-induced hyperthermia. Experimental evaluation and applications},
  url          = {http://dx.doi.org/10.1088/0031-9155/40/12/003},
  volume       = {40},
  year         = {1995},
}