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Changes in local hepatic blood perfusion during interstitial laser-induced thermotherapy of normal rat liver measured by interstitial laser Doppler flowmetry

Sturesson, C; Ivarsson, K; Andersson-Engels, Stefan LU and Tranberg, K. G (1999) In Lasers in Medical Science 14(2). p.143-149
Abstract
Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generation source. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44 degrees C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total... (More)
Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generation source. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44 degrees C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total time of 60 min. At 41 degrees C, a significant increase in perfusion up to 1.3 times the initial value was observed 2-16 min after start of treatment. At 44 degrees C, perfusion decreased continuously during and after treatment, and was significantly different from control 40 min after start of treatment. The results may be valuable in assessing the thermal response of tissues surrounding the target in interstitial laser-induced thermotherapy of liver tumours during conditions of normal blood flow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lasers in Medical Science
volume
14
issue
2
pages
143 - 149
publisher
Springer
external identifiers
  • Scopus:0032808942
ISSN
0268-8921
DOI
10.1007/s101030050036
language
English
LU publication?
yes
id
8ba8b1e6-9e3d-45b1-ab59-b835ee12640b (old id 2259445)
date added to LUP
2012-02-09 21:25:23
date last changed
2017-01-29 04:18:30
@article{8ba8b1e6-9e3d-45b1-ab59-b835ee12640b,
  abstract     = {Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generation source. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44 degrees C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total time of 60 min. At 41 degrees C, a significant increase in perfusion up to 1.3 times the initial value was observed 2-16 min after start of treatment. At 44 degrees C, perfusion decreased continuously during and after treatment, and was significantly different from control 40 min after start of treatment. The results may be valuable in assessing the thermal response of tissues surrounding the target in interstitial laser-induced thermotherapy of liver tumours during conditions of normal blood flow.},
  author       = {Sturesson, C and Ivarsson, K and Andersson-Engels, Stefan and Tranberg, K. G},
  issn         = {0268-8921},
  language     = {eng},
  number       = {2},
  pages        = {143--149},
  publisher    = {Springer},
  series       = {Lasers in Medical Science},
  title        = {Changes in local hepatic blood perfusion during interstitial laser-induced thermotherapy of normal rat liver measured by interstitial laser Doppler flowmetry},
  url          = {http://dx.doi.org/10.1007/s101030050036},
  volume       = {14},
  year         = {1999},
}