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Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery

Soto Thompson, Marcelo LU ; Andersson-Engels, Stefan LU ; Svanberg, Sune LU ; Johansson, Thomas LU ; Pålsson, Sara LU ; Bendsöe, Niels LU ; Derjabo, A ; Kapostins, J ; Stenram, U and Spigulis, J , et al. (2006) In Journal of Environmental Pathology and Toxicology 25(1-2). p.411-424
Abstract
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted... (More)
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Environmental Pathology and Toxicology
volume
25
issue
1-2
pages
411 - 424
publisher
Begell House
external identifiers
  • scopus:33644765050
ISSN
2162-6537
language
English
LU publication?
yes
id
c192e238-7db0-41ee-888d-acb330b5f4fa (old id 2259600)
date added to LUP
2016-04-04 07:26:59
date last changed
2021-09-22 05:36:07
@article{c192e238-7db0-41ee-888d-acb330b5f4fa,
  abstract     = {To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.},
  author       = {Soto Thompson, Marcelo and Andersson-Engels, Stefan and Svanberg, Sune and Johansson, Thomas and Pålsson, Sara and Bendsöe, Niels and Derjabo, A and Kapostins, J and Stenram, U and Spigulis, J and Svanberg, Katarina},
  issn         = {2162-6537},
  language     = {eng},
  number       = {1-2},
  pages        = {411--424},
  publisher    = {Begell House},
  series       = {Journal of Environmental Pathology and Toxicology},
  title        = {Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery},
  url          = {https://lup.lub.lu.se/search/ws/files/5139636/2365244.pdf},
  volume       = {25},
  year         = {2006},
}