Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery

Soto Thompson, Marcelo LU ; Andersson-Engels, Stefan LU ; Svanberg, Sune LU ; Johansson, Thomas LU ; Pålsson, Sara LU ; Bendsöe, Niels LU ; Derjabo, A ; Kapostins, J ; Stenram, U and Spigulis, J , et al. (2006) In Journal of Environmental Pathology and Toxicology 25(1-2). p.411-424
Abstract
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted... (More)
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Environmental Pathology and Toxicology
volume
25
issue
1-2
pages
411 - 424
publisher
Begell House
external identifiers
  • scopus:33644765050
ISSN
2162-6537
language
English
LU publication?
yes
id
c192e238-7db0-41ee-888d-acb330b5f4fa (old id 2259600)
date added to LUP
2016-04-04 07:26:59
date last changed
2022-01-29 02:11:16
@article{c192e238-7db0-41ee-888d-acb330b5f4fa,
  abstract     = {{To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.}},
  author       = {{Soto Thompson, Marcelo and Andersson-Engels, Stefan and Svanberg, Sune and Johansson, Thomas and Pålsson, Sara and Bendsöe, Niels and Derjabo, A and Kapostins, J and Stenram, U and Spigulis, J and Svanberg, Katarina}},
  issn         = {{2162-6537}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{411--424}},
  publisher    = {{Begell House}},
  series       = {{Journal of Environmental Pathology and Toxicology}},
  title        = {{Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery}},
  url          = {{https://lup.lub.lu.se/search/files/5139636/2365244.pdf}},
  volume       = {{25}},
  year         = {{2006}},
}