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Superficial blood flow following photodynamic therapy of malignant non-melanoma skin tumours measured by laser Doppler perfusion imaging

Wang, I; Andersson-Engels, Stefan LU ; Nilsson, G. E; Wardell, K and Svanberg, Katarina LU (1997) In British Journal of Dermatology 136(2). p.184-189
Abstract
Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue, In this study, the superficial blood perfusion of malignant nonmelanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX as a photosensitizer. The results clearly show that, in contradiction to PDT with the intravenously administered photosensitizer Photofrin, no direct vascular damage can be seen, With the topical sensitization the brood perfusion is increased immediately after the treatment irradiation. The increased brood now is seen up to a week after treatment, in a similar... (More)
Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue, In this study, the superficial blood perfusion of malignant nonmelanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX as a photosensitizer. The results clearly show that, in contradiction to PDT with the intravenously administered photosensitizer Photofrin, no direct vascular damage can be seen, With the topical sensitization the brood perfusion is increased immediately after the treatment irradiation. The increased brood now is seen up to a week after treatment, in a similar way as for an inflammatory reaction. Despite this, all basal cell carcinoma and squamous cell carcinoma in situ lesions in this study healed without any sign of residual tumour after the treatment, suggesting an efficient direct tumour cell destruction induced by PDT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Dermatology
volume
136
issue
2
pages
184 - 189
publisher
Wiley-Blackwell
external identifiers
  • scopus:0031053825
ISSN
1365-2133
DOI
10.1046/j.1365-2133.1997.d01-1166.x
language
English
LU publication?
yes
id
58327cc5-033a-4e19-96a4-c7c5a5f4cf76 (old id 2259680)
date added to LUP
2012-02-07 00:07:10
date last changed
2017-06-04 04:31:32
@article{58327cc5-033a-4e19-96a4-c7c5a5f4cf76,
  abstract     = {Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue, In this study, the superficial blood perfusion of malignant nonmelanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX as a photosensitizer. The results clearly show that, in contradiction to PDT with the intravenously administered photosensitizer Photofrin, no direct vascular damage can be seen, With the topical sensitization the brood perfusion is increased immediately after the treatment irradiation. The increased brood now is seen up to a week after treatment, in a similar way as for an inflammatory reaction. Despite this, all basal cell carcinoma and squamous cell carcinoma in situ lesions in this study healed without any sign of residual tumour after the treatment, suggesting an efficient direct tumour cell destruction induced by PDT.},
  author       = {Wang, I and Andersson-Engels, Stefan and Nilsson, G. E and Wardell, K and Svanberg, Katarina},
  issn         = {1365-2133},
  language     = {eng},
  number       = {2},
  pages        = {184--189},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Superficial blood flow following photodynamic therapy of malignant non-melanoma skin tumours measured by laser Doppler perfusion imaging},
  url          = {http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1166.x},
  volume       = {136},
  year         = {1997},
}