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Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin

Wang, I; Bauer, B; Andersson-Engels, Stefan LU ; Svanberg, Sune LU and Svanberg, Katarina LU (1999) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 77(2). p.182-188
Abstract
Purpose: Photodynamic therapy utilising delta-aminoleuvlinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin, Methods: Photodynamic therapy with laser light at 635 nm was performed in 13 patients with 19 basal cell carcinomas and one patient with 3 cutaneous T-cell lymphoma lesions. A topical application regimen was used and in median 3 treatment sessions were given to each lesion. Results: A visually judged complete response was achieved in 42 % (8/19) of the basal cell carcinomas and in 100% of the T-cell lymphoma lesions (3/3), Partial tumour response was seen in 42% (8/19) and no response in 16% (3/19) of the basal cell... (More)
Purpose: Photodynamic therapy utilising delta-aminoleuvlinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin, Methods: Photodynamic therapy with laser light at 635 nm was performed in 13 patients with 19 basal cell carcinomas and one patient with 3 cutaneous T-cell lymphoma lesions. A topical application regimen was used and in median 3 treatment sessions were given to each lesion. Results: A visually judged complete response was achieved in 42 % (8/19) of the basal cell carcinomas and in 100% of the T-cell lymphoma lesions (3/3), Partial tumour response was seen in 42% (8/19) and no response in 16% (3/19) of the basal cell carcinomas. The median follow-up time was 12 months. No, or very little scarring and loss of cilia were induced by the treatment. Conclusion: Photodynamic therapy with delta-aminolevulinic acid can eradicate eye-close non-melanoma skin malignancies without compromising the function of the eyelids. Further development of the method is needed to reach the same cure rates as those of the conventional treatment modalities. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
77
issue
2
pages
182 - 188
publisher
Wiley-Blackwell
ISSN
1395-3907
DOI
10.1034/j.1600-0420.1999.770213.x
language
English
LU publication?
yes
id
a74394f6-3d62-48a3-b35e-76c3206f520c (old id 2259685)
date added to LUP
2012-02-07 00:10:13
date last changed
2016-09-13 14:16:21
@article{a74394f6-3d62-48a3-b35e-76c3206f520c,
  abstract     = {Purpose: Photodynamic therapy utilising delta-aminoleuvlinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin, Methods: Photodynamic therapy with laser light at 635 nm was performed in 13 patients with 19 basal cell carcinomas and one patient with 3 cutaneous T-cell lymphoma lesions. A topical application regimen was used and in median 3 treatment sessions were given to each lesion. Results: A visually judged complete response was achieved in 42 % (8/19) of the basal cell carcinomas and in 100% of the T-cell lymphoma lesions (3/3), Partial tumour response was seen in 42% (8/19) and no response in 16% (3/19) of the basal cell carcinomas. The median follow-up time was 12 months. No, or very little scarring and loss of cilia were induced by the treatment. Conclusion: Photodynamic therapy with delta-aminolevulinic acid can eradicate eye-close non-melanoma skin malignancies without compromising the function of the eyelids. Further development of the method is needed to reach the same cure rates as those of the conventional treatment modalities.},
  author       = {Wang, I and Bauer, B and Andersson-Engels, Stefan and Svanberg, Sune and Svanberg, Katarina},
  issn         = {1395-3907},
  language     = {eng},
  number       = {2},
  pages        = {182--188},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin},
  url          = {http://dx.doi.org/10.1034/j.1600-0420.1999.770213.x},
  volume       = {77},
  year         = {1999},
}