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Fiber optic system for in vivo real-time determination of tissue optical properties from steady-state diffuse reflectance measurements

Dam, J. S; Pedersen, C. B; Fabricius, P. E and Andersson-Engels, Stefan LU (2000) Conference on Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography, 2000 In PHOTON MIGRATION, DIFFUSE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND FUNCTIONAL ASSESSMENT 1(31). p.103-109
Abstract
We present a versatile and compact fiber optic probe for real-time determination of the absorption and the reduced scattering coefficients from spatially resolved continuous wave diffuse reflectance measurements. The probe collects the diffuse reflectance at six distances in the range 0.6 - 7.8 mm at four arbitrary wavelengths, which were 660, 785, 805, and 974 nm in these experiments. The maximum sampling rate for one cycle of measurements including all four wavelengths is about 100 Hz. The absorption and the reduced scattering coefficients are extracted real-time from the probe measurements using multivariate calibration methods based on multiple polynomial regression and Newton-Raphson algorithms. The system was calibrated on a 6x7... (More)
We present a versatile and compact fiber optic probe for real-time determination of the absorption and the reduced scattering coefficients from spatially resolved continuous wave diffuse reflectance measurements. The probe collects the diffuse reflectance at six distances in the range 0.6 - 7.8 mm at four arbitrary wavelengths, which were 660, 785, 805, and 974 nm in these experiments. The maximum sampling rate for one cycle of measurements including all four wavelengths is about 100 Hz. The absorption and the reduced scattering coefficients are extracted real-time from the probe measurements using multivariate calibration methods based on multiple polynomial regression and Newton-Raphson algorithms. The system was calibrated on a 6x7 matrix of Intralipid/ink phantoms with optical properties within typical biological ranges, e.g. at 785 nm, the ranges of the absorption and the reduced scattering coefficients, were 0 - 0.3 /cm and 6 - 16 /cm, respectively. Cross-validation tests shoved that the mean prediction error, relative to the ranges of absorption and the reduced scattering coefficients were 2.8 \% and 1.3 \%, respectively. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
PHOTON MIGRATION, DIFFUSE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND FUNCTIONAL ASSESSMENT
editor
Andersson-Engels, S; Fujimoto, JG; and
volume
1
issue
31
pages
103 - 109
publisher
The Society of Photo-optical Instrumentation Engineers (SPIE)
conference name
Conference on Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography, 2000
external identifiers
  • scopus:0034469682
ISSN
0277-786X
1996-756X
ISBN
0-8194-3816-2
DOI
10.1117/12.407615
language
English
LU publication?
yes
id
b02386e3-1804-4694-8c07-72bb7cffbe9c (old id 2260104)
date added to LUP
2012-01-26 23:43:36
date last changed
2017-01-01 04:44:33
@inproceedings{b02386e3-1804-4694-8c07-72bb7cffbe9c,
  abstract     = {We present a versatile and compact fiber optic probe for real-time determination of the absorption and the reduced scattering coefficients from spatially resolved continuous wave diffuse reflectance measurements. The probe collects the diffuse reflectance at six distances in the range 0.6 - 7.8 mm at four arbitrary wavelengths, which were 660, 785, 805, and 974 nm in these experiments. The maximum sampling rate for one cycle of measurements including all four wavelengths is about 100 Hz. The absorption and the reduced scattering coefficients are extracted real-time from the probe measurements using multivariate calibration methods based on multiple polynomial regression and Newton-Raphson algorithms. The system was calibrated on a 6x7 matrix of Intralipid/ink phantoms with optical properties within typical biological ranges, e.g. at 785 nm, the ranges of the absorption and the reduced scattering coefficients, were 0 - 0.3 /cm and 6 - 16 /cm, respectively. Cross-validation tests shoved that the mean prediction error, relative to the ranges of absorption and the reduced scattering coefficients were 2.8 \% and 1.3 \%, respectively.},
  author       = {Dam, J. S and Pedersen, C. B and Fabricius, P. E and Andersson-Engels, Stefan},
  booktitle    = {PHOTON MIGRATION, DIFFUSE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND FUNCTIONAL ASSESSMENT},
  editor       = {Andersson-Engels, S and Fujimoto, JG},
  isbn         = {0-8194-3816-2},
  issn         = {0277-786X},
  language     = {eng},
  number       = {31},
  pages        = {103--109},
  publisher    = {The Society of Photo-optical Instrumentation Engineers (SPIE)},
  title        = {Fiber optic system for in vivo real-time determination of tissue optical properties from steady-state diffuse reflectance measurements},
  url          = {http://dx.doi.org/10.1117/12.407615},
  volume       = {1},
  year         = {2000},
}