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Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions

Thomsen, J; Bendsöe, Niels LU ; Svanberg, Katarina LU ; Andersson-Engels, Stefan LU ; Jorgensen, T. M; Thrane, L; Larsen, H. E; Pedersen, F and Andersen, P. E (2008) Conference on Biophotonics - Photonic Solution for Better Health Care, Strasbourg, FRANCE, APR 08-10, 2008 In BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE 6991.
Abstract
We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT). The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of... (More)
We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT). The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE
editor
Popp, J; Drexler, W; Tuchin, VV; Matthews, DL; ; ; and
volume
6991
publisher
SPIE
conference name
Conference on Biophotonics - Photonic Solution for Better Health Care, Strasbourg, FRANCE, APR 08-10, 2008
external identifiers
  • scopus:44949150217
ISSN
0277-786X
1996-756X
ISBN
978-0-8194-7189-5
DOI
10.1117/12.781142
language
English
LU publication?
yes
id
cf27f7c6-5407-4030-a9ca-1d95bfa0a9e6 (old id 2261109)
date added to LUP
2012-01-26 23:13:57
date last changed
2017-11-20 15:06:15
@inproceedings{cf27f7c6-5407-4030-a9ca-1d95bfa0a9e6,
  abstract     = {We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT). The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.},
  author       = {Thomsen, J and Bendsöe, Niels and Svanberg, Katarina and Andersson-Engels, Stefan and Jorgensen, T. M and Thrane, L and Larsen, H. E and Pedersen, F and Andersen, P. E},
  booktitle    = {BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE},
  editor       = {Popp, J and Drexler, W and Tuchin, VV and Matthews, DL},
  isbn         = {978-0-8194-7189-5},
  issn         = {0277-786X},
  language     = {eng},
  publisher    = {SPIE},
  title        = {Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions},
  url          = {http://dx.doi.org/10.1117/12.781142},
  volume       = {6991},
  year         = {2008},
}