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Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes

Thrane, L; Frosz, MH; Levitz, D; Jorgensen, TM; Andersen, CB; Hansen, PR; Valanciunaite, J; Swartling, Johannes LU ; Andersson-Engels, Stefan LU and Tycho, A, et al. (2005) 2004 Saratov Fall Meeting, Saratov, RUSSIA, SEP 21-24, 2004 In Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI 5771. p.139-150
Abstract
The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regimes is outlined. From this model, an algorithm for extracting tissue optical properties for multi-layered tissues is derived. The algorithm is first verified for various optical properties and geometries using solid phantoms and numerical simulations. The applicability of the algorithm for extraction of tissue optical properties is then... (More)
The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regimes is outlined. From this model, an algorithm for extracting tissue optical properties for multi-layered tissues is derived. The algorithm is first verified for various optical properties and geometries using solid phantoms and numerical simulations. The applicability of the algorithm for extraction of tissue optical properties is then demonstrated for vascular tissue samples ex vivo. With the use of data from numerical phantoms, the validity of the OCT extraction algorithm for a two-layer geometry is further supported. It is concluded that by using optical properties extracted from OCT images of human tissues, the clinical utility of OCT imaging can be substantially increased. (Less)
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
editor
Tuchin, VV and
volume
5771
pages
139 - 150
publisher
SPIE
conference name
2004 Saratov Fall Meeting, Saratov, RUSSIA, SEP 21-24, 2004
external identifiers
  • scopus:25644447436
ISSN
0277-786X
1996-756X
ISBN
0-8194-5752-3
DOI
10.1117/12.634767
language
English
LU publication?
yes
id
7a18e966-630e-4067-a0c0-6b6ec37e6590 (old id 2261128)
date added to LUP
2012-01-26 23:14:50
date last changed
2017-11-20 15:06:16
@inproceedings{7a18e966-630e-4067-a0c0-6b6ec37e6590,
  abstract     = {The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regimes is outlined. From this model, an algorithm for extracting tissue optical properties for multi-layered tissues is derived. The algorithm is first verified for various optical properties and geometries using solid phantoms and numerical simulations. The applicability of the algorithm for extraction of tissue optical properties is then demonstrated for vascular tissue samples ex vivo. With the use of data from numerical phantoms, the validity of the OCT extraction algorithm for a two-layer geometry is further supported. It is concluded that by using optical properties extracted from OCT images of human tissues, the clinical utility of OCT imaging can be substantially increased.},
  author       = {Thrane, L and Frosz, MH and Levitz, D and Jorgensen, TM and Andersen, CB and Hansen, PR and Valanciunaite, J and Swartling, Johannes and Andersson-Engels, Stefan and Tycho, A and Yura, HT and Andersen, PE},
  booktitle    = {Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI},
  editor       = {Tuchin, VV},
  isbn         = {0-8194-5752-3},
  issn         = {0277-786X},
  language     = {eng},
  pages        = {139--150},
  publisher    = {SPIE},
  title        = {Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes},
  url          = {http://dx.doi.org/10.1117/12.634767},
  volume       = {5771},
  year         = {2005},
}