Advanced

Vitronectin in host pathogen interactions and antimicrobial therapeutic applications

Singh, Birendra LU ; Su, Yu-Ching and Riesbeck, Kristian LU (2011) In Central European Journal of Biology 6(6). p.973-980
Abstract
Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel anticancer drugs. In parallel, several studies have suggested that pathogens utilize Vn in invasion of the host. Here we review the properties of Vn and its role in host-pathogen interactions that might be a future target for therapeutic intervention.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacteria, Complement system, Extracellular matrix, Innate immunity, Integrins, Vitronectin
in
Central European Journal of Biology
volume
6
issue
6
pages
973 - 980
publisher
Versita
external identifiers
  • wos:000297363300012
  • scopus:81755161453
ISSN
1895-104X
DOI
10.2478/s11535-011-0077-x
language
English
LU publication?
yes
id
2f98cfc8-45a5-420c-abd2-65dbe9780578 (old id 2272195)
date added to LUP
2012-01-02 09:48:50
date last changed
2017-07-23 03:18:28
@article{2f98cfc8-45a5-420c-abd2-65dbe9780578,
  abstract     = {Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel anticancer drugs. In parallel, several studies have suggested that pathogens utilize Vn in invasion of the host. Here we review the properties of Vn and its role in host-pathogen interactions that might be a future target for therapeutic intervention.},
  author       = {Singh, Birendra and Su, Yu-Ching and Riesbeck, Kristian},
  issn         = {1895-104X},
  keyword      = {Bacteria,Complement system,Extracellular matrix,Innate immunity,Integrins,Vitronectin},
  language     = {eng},
  number       = {6},
  pages        = {973--980},
  publisher    = {Versita},
  series       = {Central European Journal of Biology},
  title        = {Vitronectin in host pathogen interactions and antimicrobial therapeutic applications},
  url          = {http://dx.doi.org/10.2478/s11535-011-0077-x},
  volume       = {6},
  year         = {2011},
}